Plasma triglycerides, an independent predictor of cardiovascular disease in men: A prospective study based on a population with prevalent metabolic syndrome

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dc.contributor.authorOnat, Altan
dc.contributor.authorSarı, İbrahim
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorCan, Günay
dc.contributor.authorHergenç, Gülay
dc.contributor.authorAvcı, Günsel Ş.
dc.date.accessioned2020-04-30T23:21:02Z
dc.date.available2020-04-30T23:21:02Z
dc.date.issued2006
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000236475100015en_US
dc.descriptionPubMed: 16085325en_US
dc.description.abstractBackground and methods: We aimed to assess whether fasting plasma triglycerides independently predicted future fatal and nonfatal cardiovascular disease (CVD) in a population having a high prevalence of the metabolic syndrome. In the Turkish Adult Risk Factor Study, a population-based survey, 2682 men and women 20 years of age or over with fasting triglyceride values available and free of CVD at baseline examination in 1990, were prospectively followed up till 2003/04. Triglyceride concentrations were measured by the enzymatic dry chemistry method and stratified into sex-specific quintiles. Information on the mode of death was obtained from first-degree relatives and/or health personnel of local health office. Diagnosis of coronary heart disease and stroke among survivors was based on history, physical examination of the cardiovascular system and Minnesota coding of resting electrocardiograms. A total of 120 fatal and 221 new nonfatal CVD occurred among adults (mean age 43 +/- 14) during a mean 9.3 years of follow-up. Results: CVD was significantly and independently predicted by the top versus the bottom fasting triglyceride quintile in logistic regression analyses when adjusted for age, sex, BMI, systolic blood pressure, total cholesterol, lipid-lowering medication, status of smoking and of glucose regulation (relative risk [RR] in men and all adults 2.38 and 1.79, respectively, p both < 0.02). This corresponded to hazard ratios (HR) of 1.43 in men and 1.28 in men and women combined. Adjustment for HDL-cholesterol instead of total cholesterol in the same model gave also significant HRs corresponding to 1.42 in men and 1.32 in sexes combined. Conclusions: Fasting triglycerides are predictive of future CVD among men with an HR of 1.4, independent of age, diabetes, lipid-lowering medication, traditional risk factors including total cholesterol or HDL-C, in a population in which metabolic syndrome prevails. A modest independent risk increment in women did not reach significance. (c) 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijcard.2005.06.056en_US
dc.identifier.endpage95en_US
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.issue1en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2005.06.056
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4124
dc.identifier.volume108en_US
dc.identifier.wosWOS:000236475100015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectplasma triglyceridesen_US
dc.subjectpopulation-based studyen_US
dc.subjectrisk factorsen_US
dc.titlePlasma triglycerides, an independent predictor of cardiovascular disease in men: A prospective study based on a population with prevalent metabolic syndromeen_US
dc.typeArticleen_US

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