Investigation of Isoniazid, Rifampicin and Second Generation Antibiotic Resistance Genes in Rifampicin-Resistant Mycobacterium tuberculosis Complex Strains Isolated at Düzce University Between 2004-2021

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dc.contributor.authorAkbas, Emel
dc.contributor.authorEge, Nagihan
dc.contributor.authorAtik, Dursun
dc.contributor.authorCaliskan, Emel
dc.contributor.authorOksuz, Sukru
dc.contributor.authorSahin, Idris
dc.contributor.authorOzturk, Elif Cihadiye
dc.date.accessioned2025-10-11T20:47:58Z
dc.date.available2025-10-11T20:47:58Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: To determine the gene patterns causing antibiotic resistance in M. Methods: Nineteen rifampicin-resistant MTBC strains isolated between 2004 and 2021 were included. The species of these strains with MTBC genotype and the gene pattern causing rifampicin resistance with MTBDR plus genotype were analysed. Results: Nineteen of the isolates were identified as M. tuberculosis/canetti by the MTBC genotype method. Seven of these isolates were genotypically resistant to rifampicin. One of the resistant isolates had deletion in WT8 and WT6 bands, one had deletion in WT8 band, one had deletion in WT7 band and rpoBMUT2A mutation, and four had deletion in WT8 band and rpoBMUT3 mutation. Seven of the resistant isolates were genotypically INH resistant. Five of them had katGMUT1 mutation with deletion in katGWT band and two of them had only INH AMUT3B mutation. Of the 10 multidrug-resistant MTBC isolates, nine were genotypically resistant to none of the second-generation drugs using the GenoType MTBDR sl ver 2.0 method. However, one isolate could not be evaluated with this assay. Conclusions: The presence of MDR-TB and RR-TB is an important challenge especially in TB control, which increases the need for molecular methods. Although it still has not replaced culture, there is a need for the use and development of new molecular methods that will benefit us in TB treatment and control.en_US
dc.description.sponsorshipDuzce University [2022.04.01.1277]en_US
dc.description.sponsorshipSupporting Institution: Duzce University Research Fund, Project No:2022.04.01.1277en_US
dc.identifier.doi10.18521/ktd.1558505
dc.identifier.endpage99en_US
dc.identifier.issn1309-3878
dc.identifier.issue1en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.1558505
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21660
dc.identifier.volume17en_US
dc.identifier.wosWOS:001509016800012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofKonuralp Tip Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectDrug Resistanceen_US
dc.subjectMycobacterium tuberculosis Complexen_US
dc.subjectMulti-Drug Resistance Tuberculosisen_US
dc.titleInvestigation of Isoniazid, Rifampicin and Second Generation Antibiotic Resistance Genes in Rifampicin-Resistant Mycobacterium tuberculosis Complex Strains Isolated at Düzce University Between 2004-2021en_US
dc.typeArticleen_US

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