Investigation of Isoniazid, Rifampicin and Second Generation Antibiotic Resistance Genes in Rifampicin-Resistant Mycobacterium tuberculosis Complex Strains Isolated at Düzce University Between 2004-2021
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Duzce Univ, Fac Medicine
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To determine the gene patterns causing antibiotic resistance in M. Methods: Nineteen rifampicin-resistant MTBC strains isolated between 2004 and 2021 were included. The species of these strains with MTBC genotype and the gene pattern causing rifampicin resistance with MTBDR plus genotype were analysed. Results: Nineteen of the isolates were identified as M. tuberculosis/canetti by the MTBC genotype method. Seven of these isolates were genotypically resistant to rifampicin. One of the resistant isolates had deletion in WT8 and WT6 bands, one had deletion in WT8 band, one had deletion in WT7 band and rpoBMUT2A mutation, and four had deletion in WT8 band and rpoBMUT3 mutation. Seven of the resistant isolates were genotypically INH resistant. Five of them had katGMUT1 mutation with deletion in katGWT band and two of them had only INH AMUT3B mutation. Of the 10 multidrug-resistant MTBC isolates, nine were genotypically resistant to none of the second-generation drugs using the GenoType MTBDR sl ver 2.0 method. However, one isolate could not be evaluated with this assay. Conclusions: The presence of MDR-TB and RR-TB is an important challenge especially in TB control, which increases the need for molecular methods. Although it still has not replaced culture, there is a need for the use and development of new molecular methods that will benefit us in TB treatment and control.
Açıklama
Anahtar Kelimeler
Drug Resistance, Mycobacterium tuberculosis Complex, Multi-Drug Resistance Tuberculosis
Kaynak
Konuralp Tip Dergisi
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
17
Sayı
1
