Hormone replacement therapy in hypothyroidism and nerve conduction study

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dc.contributor.authorKeçeci, Hulusi
dc.contributor.authorDeğirmenci, Yıldız
dc.date.accessioned2020-05-01T12:10:24Z
dc.date.available2020-05-01T12:10:24Z
dc.date.issued2006
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000239795400004en_US
dc.descriptionPubMed: 16844546en_US
dc.description.abstractObjectives. - To evaluate the electrodiagnostic evidence of peripheral nerve dysfunction in patients with hypothyroidism before and after hormone replacement treatment. Materials and methods. - Forty patients aged above 18 years diagnosed with hypothyroidism were included in our study. Patients with FT4 levels below 11.6 pmol/l and TSH levels above 4.2 IU/ml were accepted as hypothyroidic. Electrodiagnostic evaluation was performed at the onset of the study and after 3 months. Electrodiagnostic evaluation included motor and sensory nerve conduction studies, and F wave. Results. - The differences between pre- and post-treatment FT4, FT3 and TSH values were found to be statistically significant. At the onset, electrophysiological evaluation revealed carpal tunnel syndrome in 15 patients and polyneuropathy in seven patients; whereas 18 patients were found normal in these respects. After treatment, the electrodiagnostic evaluation revealed that 35 patients were normal, while only two patients had carpal tunnel syndrome and three patients had polyneuropathy. The differences between before and after treatment values of median motor distal latency and amplitude, median sensorial nerve conduction velocity, tibia[ motor nerve conduction velocity and sural. sensory nerve conduction velocity were found to be statistically significant. Conclusion. - The results of the control evaluation after treatment demonstrated that the findings related to entrapment neuropathy and polyneuropathy in hypothyroid patients can be reversible in a period of 3 months if appropriate hormone replacement treatment can be obtained. Especially in the treatment of entrapment neuropathy in hypothyroidism, the chance of medical treatment must be given to patients before considering surgical treatment. (c) 2006 Elsevier SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.neucli.2006.04.001en_US
dc.identifier.endpage83en_US
dc.identifier.issn0987-7053
dc.identifier.issue2en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.1016/j.neucli.2006.04.001
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6180
dc.identifier.volume36en_US
dc.identifier.wosWOS:000239795400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofNeurophysiologie Clinique-Clinical Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthypothyroidismen_US
dc.subjectnerve conduction studyen_US
dc.subjectcarpal tunnel syndromeen_US
dc.subjectpolyneuropathyen_US
dc.titleHormone replacement therapy in hypothyroidism and nerve conduction studyen_US
dc.typeArticleen_US

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