Investigation of the Effect of Leaky Gut on COVID-19 Clinic

Basit Öğe Kaydı
dc.contributor.authorİnce, Nevin
dc.contributor.authorKayabaşı, Eda
dc.contributor.authorDemir, Mehmet Cihat
dc.contributor.authorCangür, Şengül
dc.contributor.authorKeskin, Banu Hümeyra
dc.contributor.authorÖztürk, C. Elif
dc.contributor.authorKaya, Sare
dc.date.accessioned2023-07-26T11:50:47Z
dc.date.available2023-07-26T11:50:47Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalıen_US
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractAim: In the course of the COVID-19 pandemic, in millions of cases were observed those of some patients do not exhibit any symptoms whereas some others are hospitalized with having fatal outcomes. One of the most significant findings is that patients with existing comorbidities are extremely exposed to severe clinical conditions developed due to excessive inflammatory response. That is to say, the indicative cause of chronic inflammation may be bacterial translocation derived from the impaired intestinal mucosal barriers. This study is aimed to investigate the probable relations between the impaired intestinal barrier integrity and which would be associated with severity of COVID-19 clinical conditions. Material and Methods: According to the clinical and laboratory findings, the patients were classified into three groups as mild, moderate, and severe clinical conditions. All patients’ blood samples were collected on the first admission to the hospital. Serum concentrations of lipopolysaccharide-binding protein (LBP), were analyzed to evaluate the intestinal barrier function and bacterial translocation. Results: The proportions of those with high LBP levels among all the groups were significantly different (p<0.001). The proportion of the patients with high LBP levels in the mild patient group (65.4%) was significantly lower than those with moderate (100%) and with severe clinical conditions (95.2%) (p<0.05 for each). Conclusion: In recent years, it has been clearly demonstrated that the functions of the intestines are much more than the digestive function, and that the intestinal microbiota and mucosal barrier integrity have a great impact on the immune system. These results would indicate that the impaired intestinal barrier integrity and bacterial translocation might be effective in severe COVID-19 development.en_US
dc.identifier.doi10.33631/sabd.1082004
dc.identifier.endpage444en_US
dc.identifier.issn2792-0542
dc.identifier.issue3en_US
dc.identifier.startpage440en_US
dc.identifier.trdizinid1124749en_US
dc.identifier.urihttp://doi.org/10.33631/sabd.1082004
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1124749
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12427
dc.identifier.volume12en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorİnce, Nevin
dc.institutionauthorKeskin, Banu Hümeyra
dc.institutionauthorKayabaşı, Eda
dc.institutionauthorKaya, Sare
dc.institutionauthorCangür, Şengül
dc.institutionauthorDemir, Mehmet Cihat
dc.institutionauthorGülhan, Pınar Yıldız
dc.language.isoenen_US
dc.relation.ispartofSağlık bilimlerinde değer (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectBacterial translocationen_US
dc.subjectCOVID-19en_US
dc.subjectinnate immunityen_US
dc.subjectleaky guten_US
dc.subjectSARS-CoV-2en_US
dc.titleInvestigation of the Effect of Leaky Gut on COVID-19 Clinicen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
12427.pdf
Boyut:
665 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
Sağlık bilimlerinde değer (Online) Koleksiyonu