Biodegradable Poly(epsilon-Caprolactone)-Based Graft Copolymers Via Poly(Linoleic Acid): In Vitro Enzymatic Evaluation

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dc.contributor.authorAllı, Sema
dc.contributor.authorAydın, Rahime Seda Tığlı
dc.contributor.authorAllı, Abdulkadir
dc.contributor.authorHazer, Baki
dc.date.accessioned2020-04-30T22:40:11Z
dc.date.available2020-04-30T22:40:11Z
dc.date.issued2015
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionAydin, Seda Tigli/0000-0002-4184-5320en_US
dc.descriptionWOS: 000350563400016en_US
dc.description.abstractWell-defined graft copolymers based on poly(epsilon-caprolactone) (PCL) via poly(linoleic acid) (PLina), are derived from soybean oil. Poly(linoleic acid)-g-poly(epsilon-caprolactone) (PLina-g-PCL) and poly(linoleic acid)-g-poly(styrene)-g-poly(epsilon-caprolactone) (PLina-g-PSt-g-PCL) were synthesized by ring-opening polymerization of epsilon-caprolactone initiated by PLina and one-pot synthesis of graft copolymers, and by ring-opening polymerization and free radical polymerization by using PLina, respectively. PLina-g-PCL, PLina-g-PSt-g-PCL3, and PLina-g-PSt-g-PCL4 copolymers containing 96.97, 75.04 and 80.34 mol% CL, respectively, have been investigated regarding their enzymatic degradation properties in the presence of Pseudomonas lipase. In terms of weight loss, after 1 month, 51.5 % of PLina-g-PCL, 18.8 % of PLina-g-PSt-g-PCL3, and 38.4 % of PLina-g-PSt-g-PCL4 were degraded, leaving remaining copolymers with molecular weights of 16,140, 83,220 and 70,600 Da, respectively. Introducing the PLina unit into the copolymers greatly decreased the degradation rate. The molar ratio of [CL]/[Lina] dramatically decreased, from 21.3 to 8.4, after 30 days of incubation. Moreover, reduced PCL content in PLina-g-PSt-g-PCL copolymers decreased the degradation rate, probably due to the PSt enrichment within the structure, which blocks lipase contact with PCL units. Thus, copolymerization of PCL with PLina and PSt units leads to a controllable degradation profile, which encourages the use of these polymers as promising biomaterials for tissue engineering applications.en_US
dc.description.sponsorshipTurkish Scientific Research CouncilTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [110T884, 211T016]; Bulent Ecevit University Research FundBulent Ecevit University [2012-17-21-03]en_US
dc.description.sponsorshipThis work was supported financially by the Turkish Scientific Research Council (Grants Numbers: 110T884, 211T016) and Bulent Ecevit University Research Fund (Grant Number: 2012-17-21-03).en_US
dc.identifier.doi10.1007/s11746-015-2611-xen_US
dc.identifier.endpage458en_US
dc.identifier.issn0003-021X
dc.identifier.issn1558-9331
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage449en_US
dc.identifier.urihttps://doi.org/10.1007/s11746-015-2611-x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2926
dc.identifier.volume92en_US
dc.identifier.wosWOS:000350563400016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of The American Oil Chemists Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEnzymatic degradationen_US
dc.subjectPoly(epsilon-caprolactone)en_US
dc.subjectPoly(linoleic acid)en_US
dc.subjectPoly(styrene)en_US
dc.titleBiodegradable Poly(epsilon-Caprolactone)-Based Graft Copolymers Via Poly(Linoleic Acid): In Vitro Enzymatic Evaluationen_US
dc.typeArticleen_US

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