Akut Pankreatit Şiddeti ile Trombosit Lenfosit Oranı, Nötrofil Lenfosit Oranı, Eritrosit Dağılım Genişliği ve Ortalama Platelet Volümü Arasındaki İlişki
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2019
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info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada sistemik inflamasyon ile ilişkili bir marker olduğu gösterilen; Nötrofillenfosit oranı (NLR), platelet-lenfosit oranı (PLR), ortalama trombosit hacmi (MPV) veEritrosit dağılım hacmi (RDW) ile akut pankreatitin (AP) başvuru anındaki ciddiyetinigösteren Ranson kriteri ile aralarındaki ilişkinin gösterilmesi amaçlanmıştır.Gereç ve Yöntem: Ocak 2017 ile Kasım 2018 tarihleri arasında AP tanısı ile takip edenhastaların verilerine retrospektif olarak ulaşıldı. 82 biliyer ve 15 nonbiliyer olmak üzeretoplam 139 hasta çalışmaya alındı. Hastaların ilk başvuru anında bakılan hemogram vebiyokimyasal parametreleri, yaşları, cinsiyetleri, ko-morbiditeleri ve yatış süreleri kaydedildi.İlk başvuru anında bakılan Ranson Kriterlerine göre skoru < 3 ve skoru ? 3 pozitif olanlarolmak üzere 2 gruba ayrıldı ve bu gruplar karşılaştırıldı.Bulgular: AP tanısı ile takip edilen 139 hastanın 75 (%54)’i erkek, 64 (%46)’ü kadındı.Hastaların 113’ü Ranson kriterlerine göre 3’ün altında 26’sı ise 3 ve üzerindeydi. Ortalamayaş hafif AP grubunda 61±20 yıl, şiddetli AP grubunda ise 70±13 yıldı. MPV (P< 0.001) veNLR (P< 0.001) değerleri gruplar arasında anlamlı olarak farklı saptandı. Korelasyonanalizinde; NLR ile ranson skoru arasında pozitif korelasyon saptandı (r= 0,253 p<0,01).Yapılan Lineer Regresyon analizi sonucunda, NLR ve PLR’nin AP şiddetini göstermedebağımsız prediktör oldukları bulundu.Sonuç: Sistemik inflamasyonu gösteren çalıştığımız parametrelerden NLR, AP’nin şiddetinibelirlemede basit ve güvenilir bir gösterge olarak kullanılabilir.
Objective: In this study we have shown that there is a marker associated with systemic inflammation; The aim of this study was to determine the relationship between neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), mean platelet volume (MPV) and Erythrocyte distribution volume (RDW) and Ranson Criteria showing the severity of acute pancreatitis (AP) at the time of presentation. Methods: The data of the patients who were diagnosed with AP between January 2017 and November 2018 were retrospectively obtained. A total of 139 patients (82 biliary and 15 nonbiliary) were included in the study. Hemogram and biochemical parameters, age, gender, co-morbidities and duration of hospitalization were recorded. According to the Ranson Criteria used at the time of admission score < 3 and score ? 3 positive and these groups were compared. Results: Of the 139 patients diagnosed with AP, 75 (54%) were male and 64 (46%) were female. 113 of the patients were divided into two groups according to the Ranson criteria. The mean age was 61 ±20 years in the mild AP group and 70 ±13 years in the severe AP group. MPV (P <0.001), NLR (P <0.001) values were significantly different between the groups. In the correlation analysis; there was a positive correlation between NLR and ranson score (r = 0.253 p <0.01). Linear regression analysis showed that, NLR and PLR were independent predictors of acute pancreatitis. Conclusion: NLR can be used as a simple and reliable indicator in determining the severity of AP.
Objective: In this study we have shown that there is a marker associated with systemic inflammation; The aim of this study was to determine the relationship between neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), mean platelet volume (MPV) and Erythrocyte distribution volume (RDW) and Ranson Criteria showing the severity of acute pancreatitis (AP) at the time of presentation. Methods: The data of the patients who were diagnosed with AP between January 2017 and November 2018 were retrospectively obtained. A total of 139 patients (82 biliary and 15 nonbiliary) were included in the study. Hemogram and biochemical parameters, age, gender, co-morbidities and duration of hospitalization were recorded. According to the Ranson Criteria used at the time of admission score < 3 and score ? 3 positive and these groups were compared. Results: Of the 139 patients diagnosed with AP, 75 (54%) were male and 64 (46%) were female. 113 of the patients were divided into two groups according to the Ranson criteria. The mean age was 61 ±20 years in the mild AP group and 70 ±13 years in the severe AP group. MPV (P <0.001), NLR (P <0.001) values were significantly different between the groups. In the correlation analysis; there was a positive correlation between NLR and ranson score (r = 0.253 p <0.01). Linear regression analysis showed that, NLR and PLR were independent predictors of acute pancreatitis. Conclusion: NLR can be used as a simple and reliable indicator in determining the severity of AP.
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