Synthesis and characterization of cryogels of p(HEMA-N-vinylformamide) and p(HEMA-N-Vinylpyrrolidone) for chemical release behaviour

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dc.authoridSarkaya, Koray/0000-0003-0177-5134
dc.contributor.authorSarkaya, Koray
dc.contributor.authorAlli, Abdulkadir
dc.date.accessioned2021-12-01T18:47:03Z
dc.date.available2021-12-01T18:47:03Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractMacroporous polymeric gels has received great attention in many fields focused on biotechnological applications. In this study, two new HEMA-based cryogel columns were synthesized. To this end, poly(HEMA-VF) and poly(HEMA-NVP) cryogels were prepared by copolymerization of 2-Hydroxyethyl methacrylate (HEMA) with N-vinylformamide (VF) and N-vinylpyrrolidone (VP) in the presence of N,N-methylenebisacrylamide (as cross-linker), then polymerization initiated by ammonium persulfate (APS) and N,N,N ',N '-tetramethylenediamine (TEMED) with free-radical polymerizations method in cryogelation conditions, respectively. p(HEMA-VF) and p(HEMA-VP) cryogels contain a continuous polymeric matrix with interconnected pores of size 2-100 mu m. Swelling behavior for these cryogels in various solvents was investigated, wherein the characterization of the cryogels is conducted via by surface area measurement (BET), Fourier transforms infrared spectroscopy (FT-IR), elemental analysis, scanning electron microscopy (SEM), Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). As drug model compounds, Methyl Red (MR), methylene blue (MB) and methylene green (MG) were loaded into prepared cryogels and the controlled release properties of cryogel columns were examined comparatively each other. It has been shown that approximately 90% of its release from the cryogels occurred within about 2 h. In addition, MB release from p(HEMA-VF) and p(HEMA-VP) cryogels was found to be around 80% over a similar period. The proposed cryogels can be regarded as controlled release system on future biomedical applications.en_US
dc.description.sponsorshipDuzce University Research FundDuzce University [2019.05.03.1024]en_US
dc.description.sponsorshipThis work was supported financially by the Duzce University Research Fund (Grant Number 2019.05.03.1024).en_US
dc.identifier.doi10.1007/s10934-021-01037-9
dc.identifier.endpage865en_US
dc.identifier.issn1380-2224
dc.identifier.issn1573-4854
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85100293367en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage853en_US
dc.identifier.urihttps://doi.org/10.1007/s10934-021-01037-9
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10117
dc.identifier.volume28en_US
dc.identifier.wosWOS:000614319600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Porous Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug delivery systemsen_US
dc.subjectN-vinylformamide (VF)en_US
dc.subjectN-vinylpyrrolidone (VP)en_US
dc.subjectSupermacroporous cryogelen_US
dc.titleSynthesis and characterization of cryogels of p(HEMA-N-vinylformamide) and p(HEMA-N-Vinylpyrrolidone) for chemical release behaviouren_US
dc.typeArticleen_US

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