HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia

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dc.contributor.authorAkdemir, Ramazan
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorGündüz, Hüseyin
dc.contributor.authorErbilen, Enver
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorDuran, Sadık
dc.contributor.authorUyan, Cihangir
dc.date.accessioned2020-05-01T12:10:23Z
dc.date.available2020-05-01T12:10:23Z
dc.date.issued2004
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000224482800004en_US
dc.descriptionPubMed: 15529553en_US
dc.description.abstractObjectives - The purpose of our study was to evaluate the significance of polymorphisms in HLA class II genes in coronary artery ectasia (CAE) patients. Methods and results - Twenty-six patients with CAE without associated cardiac defects were enrolled in the study. CAE was defined as luminal dilation of 1.5- to 2.0-fold of normal limits. Ninety-five healthy subjects who were donors for different organ transplantations, were chosen as control group. Physical examination, electrocardiography and chest X-ray were completely normal in these cases. Both the patients and the control group were screened and compared for their HLA class II genotypes. HLA-DR BI * 13, DR 16, DQ2 and DQ5 genotypes were significantly more frequent in the patient group. When the known risk factors of coronary heart disease were compared in the patients carrying these genotypes with the non-carrying group, no significant differences were encountered. Conclusions - HLA-DR BI * 13, DR 16, DQ2 and DQ5 may be associated with the pathogenesis and increase the risk of CAE.en_US
dc.identifier.doi10.2143/AC.59.5.2005222en_US
dc.identifier.endpage502en_US
dc.identifier.issn0001-5385
dc.identifier.issue5en_US
dc.identifier.startpage499en_US
dc.identifier.urihttps://doi.org/10.2143/AC.59.5.2005222
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6176
dc.identifier.volume59en_US
dc.identifier.wosWOS:000224482800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cardiologicaen_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHLAen_US
dc.subjectcoronary artery ectasiaen_US
dc.titleHLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasiaen_US
dc.typeArticleen_US

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