Relationship between subjective sleep quality and serum ghrelin levels in Parkinson's disease

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dc.contributor.authorAyasli, Alper
dc.contributor.authorDegirmenci, Yildiz
dc.contributor.authorFat, Davran
dc.contributor.authorSungur, Mehmet Ali
dc.date.accessioned2025-10-11T20:47:36Z
dc.date.available2025-10-11T20:47:36Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjectives: This study aimed to investigate the relationship between serum ghrelin levels and subjective sleep quality in patients with Parkinson's disease (PD). Patients and methods: This prospective case-control study was conducted between July 2020 and September 2021. Sixty-three patients (39 males, 24 females; mean age: 64.8 +/- 12.8; range, 52 to 76 years) diagnosed with idiopathic PD and 59 healthy participants (34 males, 25 females; mean age: 63.9 +/- 6.2 years; range, 57 to 59 years) were included in the study. The patients' modified Hoehn and Yahr and Unified Parkinson's Disease Rating Scale scores were determined. Subjective sleep quality of study groups was evaluated with the Pittsburgh Sleep Quality Index, and serum fasting ghrelin levels were measured. Results: The patient and control groups did not show any significant differences in terms of sociodemographic characteristics. The Pittsburgh Sleep Quality Index values of the patient group were higher compared to the control group (p <= 0.001). There was no significant difference between serum ghrelin levels (p=0.329). Conclusion: A significant relationship was not identified between subjective sleep quality and serum ghrelin levels in PD, and ghrelin did not support the diagnosis of PD. Further studies with larger samples that account for the variability in food intake and the timing of serum ghrelin measurements are needed.en_US
dc.identifier.doi10.55697/tnd.2025.137
dc.identifier.endpage75en_US
dc.identifier.issn1301-062X
dc.identifier.issn1309-2545
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-105001102701en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.55697/tnd.2025.137
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21471
dc.identifier.volume31en_US
dc.identifier.wosWOS:001456073700010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal of Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectGhrelinen_US
dc.subjectParkinson's diseaseen_US
dc.subjectsleep qualityen_US
dc.titleRelationship between subjective sleep quality and serum ghrelin levels in Parkinson's diseaseen_US
dc.typeArticleen_US

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