The effects of leptin on the cardiovascular system

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dc.authorscopusid57194432176en_US
dc.authorscopusid57219390008en_US
dc.authorscopusid6507629512en_US
dc.authorscopusid58016862300en_US
dc.contributor.authorKiliç, U.
dc.contributor.authorSoytürk, H.
dc.contributor.authorSuveren, E.
dc.contributor.authorYildiz, A.
dc.date.accessioned2024-08-23T16:07:41Z
dc.date.available2024-08-23T16:07:41Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractLeptin hormone is an adipokine released from adipose tissue that has recently gained interest due to its impact on the cardiovascular system as well as many other systemic effects. The obesity (ob) gene regulates leptin hormone release, which plays a role in body fat regulation. Obesity, which is defined by a rise in blood leptin levels, is a key risk factor for cardiovascular disease. Because of the increased activity of the sympathetic nervous system and the accompanying renin-angiotensin system, obesity produces a rise in extracellular fluid volume. The increase in sympathetic activity caused by hyperleptinemia is one of the reasons for obesity-related hypertension. One of the reasons for cardiovascular diseases in obesity is the interplay of angiotensin II, insulin, endothelin-A, and hyperleptinemia. Acute cardiovascular events, restenosis following coronary angioplasty, and cerebral palsy have all been linked to high leptin levels. In leptin-deficient mice, arterial thrombosis was shown to be minimal. As a result, inhibiting leptin activation could be a future therapy method for hyperleptinemic obese people to reduce the course of atherosclerosis. This book chapter will discuss the consequences of hyperleptinemia caused by high leptin serum levels and leptin receptor resistance in obesity on renal, cardiac, vascular, and sympathetic nervous system function, as well as their relationship to cardiovascular disease. © 2024 by Nova Science Publishers, Inc. All rights reserved.en_US
dc.identifier.endpage79en_US
dc.identifier.isbn979-889113334-1en_US
dc.identifier.isbn979-889113274-0en_US
dc.identifier.scopus2-s2.0-85183082504en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14789
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNova Science Publishers, Inc.en_US
dc.relation.ispartofLeptin and its Role in Health and Diseaseen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular diseasesen_US
dc.subjectHypertensionen_US
dc.subjectLeptinen_US
dc.subjectObesityen_US
dc.subjectSympathetic nervous systemen_US
dc.titleThe effects of leptin on the cardiovascular systemen_US
dc.typeBook Chapteren_US

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