The effects of leptin on the cardiovascular system
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nova Science Publishers, Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Leptin hormone is an adipokine released from adipose tissue that has recently gained interest due to its impact on the cardiovascular system as well as many other systemic effects. The obesity (ob) gene regulates leptin hormone release, which plays a role in body fat regulation. Obesity, which is defined by a rise in blood leptin levels, is a key risk factor for cardiovascular disease. Because of the increased activity of the sympathetic nervous system and the accompanying renin-angiotensin system, obesity produces a rise in extracellular fluid volume. The increase in sympathetic activity caused by hyperleptinemia is one of the reasons for obesity-related hypertension. One of the reasons for cardiovascular diseases in obesity is the interplay of angiotensin II, insulin, endothelin-A, and hyperleptinemia. Acute cardiovascular events, restenosis following coronary angioplasty, and cerebral palsy have all been linked to high leptin levels. In leptin-deficient mice, arterial thrombosis was shown to be minimal. As a result, inhibiting leptin activation could be a future therapy method for hyperleptinemic obese people to reduce the course of atherosclerosis. This book chapter will discuss the consequences of hyperleptinemia caused by high leptin serum levels and leptin receptor resistance in obesity on renal, cardiac, vascular, and sympathetic nervous system function, as well as their relationship to cardiovascular disease. © 2024 by Nova Science Publishers, Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Cardiovascular diseases, Hypertension, Leptin, Obesity, Sympathetic nervous system
Kaynak
Leptin and its Role in Health and Disease
WoS Q Değeri
Scopus Q Değeri
N/A
