The Relationship of Lactate Levels with Carboxyhemoglobin Levels and Clinical Findings in Patients Admitted with Acute Carbon Monoxide Poisoning
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Tarih
2021
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info:eu-repo/semantics/openAccess
Özet
Aim: Acute carbon monoxide (CO) poisoning is a potentially mortal, though preventable,condition. Mild poisoning presents with non-specific symptoms, such as fatigue, headache,nausea and vomiting, whereas severe exposure to CO can result in loss of consciousness, coma,and death. The aim of this study was to investigate the utility of lactate and carboxyhemoglobin(COHb) levels in the clinical presentation and treatment of patients with acute CO poisoning.Material and Methods: Data were obtained from the hospital information system and patientfiles with ICD-10 code “T58: Toxic effects of CO”. The blood parameters and vital signs ofpatients at admission, causes of poisoning, time to hospital, and Glasgow coma scores duringadmission were recorded. Within related and relevant complications of CO intoxication anddata concerning treatment plans and hospitalization status were recorded.Results: A statistically significant difference was found between COHb and lactate levels ofpatients who did and did not develop neurological and cardiac complications (p<0.001).Moreover, a statistically significant difference was found in COHb and lactate levels amongpatients who did or did not receive hyperbaric oxygen therapy, and who were hospitalized ornot (p<0.001). As looking for biochemical profile, significant correlations was found betweenCOHb and pH, base excess, and bicarbonate and lactate levels.Conclusion: This study shows that COHb and lactate levels at admission to the emergencydepartment are significant for prognosis, follow-up, and treatment of patients with COpoisoning. Elevated lactate and COHb levels may also found to be associated with neurologicaland cardiac complications.
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23
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1
