The Effects of Vitamin E on Antioxidant Enzyme Activity in HepG2 Cells

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dc.contributor.authorBalkan, Burcu Menekşe
dc.contributor.authorKısmalı, Görkem
dc.contributor.authorAlpay, Merve
dc.contributor.authorSayıner, Serkan
dc.contributor.authorTuran, Deniz
dc.contributor.authorBalkan, Ali Burak
dc.contributor.authorSel, Tevhide
dc.date.accessioned2020-04-30T23:33:35Z
dc.date.available2020-04-30T23:33:35Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionSayiner, Serkan/0000-0002-3297-5369; SALMANOGLU, BERRIN/0000-0003-4344-5782en_US
dc.descriptionWOS: 000382113800009en_US
dc.description.abstractIt is aimed to investigate the effect of vitamin E, powerful antioxidant (alpha-tocopherol succinate) on antioxidant enzyme activities in hepatocellular carcinoma (HepG2) cells. The hepatocellular carcinoma cell line HepG2 was used and the cells were cultured in the absence (control) or presence of different dose of vitamin E (50 mM, 50 mu M and 10 mu M vitamin E) for 24 h. The effect of vitamin E (alpha-tocopherol succinate) on catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities in hepatocarcinoma cells were measured by spectrophotometry. A significant decrease in GPx activity was detected in 50 mM vitamin E treated HepG2 cells. However a significant decrease occurred in 10 mu M and 50 mu M vitamin E applied HepG2 cells. SOD activity in study groups were lower than in control cells. In addition to this, the decrease in SOD activity in 50 mM vitamin E applied cells was significant. CAT enzyme activity in 50 mu m vitamin E applied HepG2 cells was higher and, in 10 mu M and 50 mM vitamin E applied HepG2 cells were lower than in control group. It was determined that vitamin E has a dose-dependent effect on antioxidant enzyme activity in HepG2 cells.en_US
dc.identifier.doi10.9775/kvfd.2016.15499en_US
dc.identifier.endpage869en_US
dc.identifier.issn1300-6045
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage865en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2016.15499
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5001
dc.identifier.volume22en_US
dc.identifier.wosWOS:000382113800009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCatalaseen_US
dc.subjectGlutathione Peroxidaseen_US
dc.subjectHepG2en_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectVitamin Een_US
dc.titleThe Effects of Vitamin E on Antioxidant Enzyme Activity in HepG2 Cellsen_US
dc.typeArticleen_US

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