Formulation, Optimization, and In-Vitro Evaluation of Hyaluronic Acid Buccal Films Containing Benzydamine Hydrochloride

Basit Öğe Kaydı
dc.contributor.authorKaraküçük, Alptuğ
dc.contributor.authorTort, Serdar
dc.date.accessioned2023-04-10T20:30:59Z
dc.date.available2023-04-10T20:30:59Z
dc.date.issued2021
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: Mucoadhesive buccal films provide drug delivery for both local and systemic circulation with increased patientcompliance. The objective of this study was to develop a buccal film containing benzydamine hydrochloride (BNZ) byusing hyaluronic acid (HA) as a film-forming agent and glycerin (Gly) as a plasticizer for the anti-inflammatory effect onthe mucosal ulcer.Material and Methods: The effects of different concentrations of HA and Gly on responses were analyzed using 23factorial design. The HA and Gly ratio were selected as independent factors, and work of mucoadhesion, tensile strength,elongation at break, and contact angle values were chosen as dependent factors. Nine different film formulations wereprepared at constant BNZ concentration (0.15%) by solvent casting method. Mechanical and mucoadhesion properties offilm formulations were evaluated, and also contact angles were calculated. The BNZ release profiles were evaluated insimulated saliva solution (pH 6.8).Results: All film formulations were successfully prepared by solvent casting method. Increasing HA concentration from0.5 to 2 % raised the mechanical and mucoadhesion properties of film formulations. Although the addition of Glydecreased the tensile strength values, it increased the elongation at break values about ten times. All formulationsreleased more than 60 % BNZ in 60 mins.Conclusion: It is concluded that HA oral mucoadhesive film formulations containing BNZ are promising for treatingoral ulcers.en_US
dc.identifier.doi10.33631/duzcesbed.833024
dc.identifier.endpage330en_US
dc.identifier.issn2146-443X
dc.identifier.issn2146-443X
dc.identifier.issue3en_US
dc.identifier.startpage325en_US
dc.identifier.trdizinid453715en_US
dc.identifier.urihttp://doi.org/10.33631/duzcesbed.833024
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/453715
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12008
dc.identifier.volume11en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbuccal filmen_US
dc.subjectsolvent casting methoden_US
dc.subjecthyaluronic aciden_US
dc.subjectBenzydamine hydrochlorideen_US
dc.titleFormulation, Optimization, and In-Vitro Evaluation of Hyaluronic Acid Buccal Films Containing Benzydamine Hydrochlorideen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
12008.pdf
Boyut:
757.44 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Koleksiyonu