Efficacy of Topical Sodium Sulfacetamide in the Treatment of Mild and Moderate Acne Vulgaris: A Randomized, Comparative Study

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dc.contributor.authorTuran, Ayşegül
dc.contributor.authorSancaoğlu, Hayriye
dc.contributor.authorBaşkan, Emel Bülbül
dc.contributor.authorTuran, Hakan
dc.contributor.authorAydoğan, Kenan
dc.date.accessioned2020-05-01T09:12:08Z
dc.date.available2020-05-01T09:12:08Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAydogan, Kenan/0000-0002-0193-1128en_US
dc.descriptionWOS: 000301968600009en_US
dc.description.abstractBackground and Design: Clindamycin and erythromycin are the most widely used topical antibiotics in the treatment of mild to moderate acne vulgaris. The combination of topical antibiotics with benzoyl peroxide increases the efficacy of the treatment and reduces antibiotic resistance of Propionibacterium acnes. Sodium sulfacetamide is a sulfonamide antibiotic. Although it has been known for many years, it is not widely used in acne treatment. However, it has recently acquired currency again. In this study, we aimed to assess the efficacy of sodium sulfacetamide in the treatment of mild to moderate acne vulgaris and to compare with the other widely used topical antibiotics. Material and Method: In our comparative study, 60 patients with acne vulgaris were randomly assigned into 3 groups, wherein the 1st, 2nd, and 3rd groups were applied sodium sulfacetamide 10% lotion, clindamycin 1% lotion, and erythromycin 2% gel, respectively, twice daily for 12 weeks. Each group consisted of 20 subjects. The treatment was combined with benzoyl peroxide in all groups. The patients were assessed for noninflammatory (open and closed comedones) and inflammatory (papules and pustules) lesion counts at 4, 8, and 12 weeks and, adverse events were recorded. Results: There was no significant difference between the groups for age, sex and acne duration (p>0.05). Statistically significant decrease was obtained with all 3 treatment regimens at the end of the study (p<0.05). No significant difference was detected between the 3 groups regarding noninflammatory and total lesion counts at 4, 8, and 12 weeks, however, clindamycin was superior to other treatments at the 8th week regarding inflammatory lesion counts (p<0.05). There was no statistically significant difference in adverse effect rates between the three groups (p>0.05). Conclusion: In this study, topical sodium sulfacetamide was found to be as effective and safe as erythromycin and clindamycin when combined with benzoyl peroxide in the treatment of mild to moderate acne vulgaris. These results should be supported by studies with larger cohorts. (Turkderm 2012; 46: 33-8)en_US
dc.identifier.doi10.4274/turkderm.77698en_US
dc.identifier.endpage38en_US
dc.identifier.issn1019-214X
dc.identifier.issn1308-6294
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.4274/turkderm.77698
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5889
dc.identifier.volume46en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkish Soc Dermatology Venerologyen_US
dc.relation.ispartofTurkderm-Turkish Archives Of Dermatology And Venerologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcneen_US
dc.subjectbenzoyl peroxideen_US
dc.subjectclindamycinen_US
dc.subjecterythromycinen_US
dc.subjectsodium sulfacetamideen_US
dc.subjecttreatmenten_US
dc.titleEfficacy of Topical Sodium Sulfacetamide in the Treatment of Mild and Moderate Acne Vulgaris: A Randomized, Comparative Studyen_US
dc.typeArticleen_US

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