In vitro cytotoxic and genotoxic effects of newly synthesised boron ionic liquids

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dc.contributor.authorOğuzkan, Sibel Bayıl
dc.contributor.authorTürkez, Hasan
dc.contributor.authorKaragül, Bora
dc.contributor.authorÇakır, Ümit
dc.contributor.authorUğraş, Halil İbrahim
dc.date.accessioned2020-04-30T23:18:27Z
dc.date.available2020-04-30T23:18:27Z
dc.date.issued2019
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionoguzkan, sibel Bayil/0000-0003-0254-6915; ugras, halil ibrahim/0000-0002-1633-967Xen_US
dc.descriptionWOS: 000475341200001en_US
dc.description.abstractIn this study, new molecules containing boron were added to the family of ionic organic compounds, in particular, ionic liquids with a cationic center. This study aimed to determine the cytotoxic and genetic effects of a total of four newly synthesised borenium and borinium compounds on human peripheral lymphocytes in vitro. Human peripheral lymphocytes were obtained from heparinised blood samples collected from healthy females aged between 29 and 32 years, with no history of exposure to toxic agents. The cytotoxicity was assayed via the MTT (3-(4.5-dimethylthiazole- 2-yl)-2.5-diphenyltetrazolium-bromide) and LDH (lactate dehydrogenase) tests; the genotoxicity and cytotoxicity, via the micronucleus (MN) and sister chromatid exchange (SCE) tests. The results showed that the borenium compounds did not exhibit cytotoxic activity in the MTT and LDH tests even in high concentrations, the borinium compound did not exhibit cytotoxic effects in lower concentrations in vitro. The borenium compounds did not show genotoxic effects in SCE and MN tests. However, at a high concentration, borinium increased the micronucleus rate in comparison to the negative control group. The obtained results suggest that these newly synthesised cationic boron compounds can be used reliably in health, cosmetics or other industries, taking into consideration their types and concentrations.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114M933]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under grant number 114M933.en_US
dc.identifier.doi10.1080/13102818.2018.1552195en_US
dc.identifier.endpage92en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage86en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2018.1552195
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3326
dc.identifier.volume33en_US
dc.identifier.wosWOS:000475341200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBoreniumen_US
dc.subjectboriniumen_US
dc.subjectMTTen_US
dc.subjectLDHen_US
dc.subjectmicronucleien_US
dc.subjectsister chromatid exchangeen_US
dc.titleIn vitro cytotoxic and genotoxic effects of newly synthesised boron ionic liquidsen_US
dc.typeArticleen_US

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