Chemical Composition and In Vitro Antimicrobial, Antioxidant, and Antiproliferative Studies of the Lamium galeobdolon L. (L.) Essential Oil

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dc.contributor.authorAkkoyunlu, A.
dc.contributor.authorDülger, Görkem
dc.date.accessioned2023-07-26T11:58:06Z
dc.date.available2023-07-26T11:58:06Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe current study aimed to evaluate the chemical composition and bioactive properties of Lamium galeobdolon (L.) L. After obtaining an ethanol extract, analysis of its chemical composition was carried out via gas chromatography-mass spectroscopy (GC-MS), which identified 2(3H)-benzoxazolone, palmitic acid, 3,7,11,15-tetramethyl-2-hexadecen-1-ol, eicosane, 9,12-octadecadienoic acid, and tetracosane as major components. In addition, the antioxidant and oxidant capacities of the essential oil were determined using the total antioxidant status (TAS) and the total oxidant status (TOS) kits, and the oxidative stress index (OSI) value was calculated from the ratio of the two. The OSI value of L. galeobdolon (L.) L. was found to be 0.987 arbitrary units (AU). Essential oil was obtained from the plant and the antimicrobial and antiproliferative effects of this oil were investigated. The antiproliferative activity was determined via MTT assay on the B16F10 cell line. The maximum cell death was observed as 88.9% at a concentration of 50 mu g/mL. The antimicrobial activity was determined via the disc diffusion method. Accordingly, no antibacterial activity was found; however, the antifungal effect of the plant was significant.en_US
dc.description.sponsorshipDuzce University [2019.04.01.900]en_US
dc.description.sponsorshipThis study was supported by the Duzce University (Project no. 2019.04.01.900).en_US
dc.identifier.doi10.1134/S1068162022060048
dc.identifier.endpage1246en_US
dc.identifier.issn1068-1620
dc.identifier.issn1608-330X
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85140234546en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1240en_US
dc.identifier.urihttps://doi.org/10.1134/S1068162022060048
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13399
dc.identifier.volume48en_US
dc.identifier.wosWOS:000870655000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAkkoyunlu, A.
dc.institutionauthorDülger, Görkem
dc.language.isoenen_US
dc.publisherMaik Nauka/Interperiodica/Springeren_US
dc.relation.ispartofRussian Journal of Bioorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectLamium Galeobdolon (L; ) L; Gc-Ms Analysis; Mtt; Tas-Tos; Disc Diffusionen_US
dc.subjectConstituentsen_US
dc.titleChemical Composition and In Vitro Antimicrobial, Antioxidant, and Antiproliferative Studies of the Lamium galeobdolon L. (L.) Essential Oilen_US
dc.typeArticleen_US

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