Characterization of essential oils from medicinal plants and assessment of their antimutagenic effects using Ames salmonella/microsomal test

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dc.authoridgoc rasgele, pınar/0000-0002-7558-3138en_US
dc.authorscopusid15136582600en_US
dc.authorscopusid14032910900en_US
dc.authorwosidgoc rasgele, pınar/S-8923-2016en_US
dc.contributor.authorGöç Rasgele, Pınar
dc.contributor.authorAltin, Nedim
dc.date.accessioned2024-08-23T16:03:22Z
dc.date.available2024-08-23T16:03:22Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractWe investigated the antimutagenic activities and chemical compositions of essential oil (EO) from Melissa officinalis, Lavandula angustifolia and Orig-anum onites plants belonging to the Lamiaceae family. The chemical compo-sitions of the plants were determined by GC/MS analysis and Ames assay was used in antimutagenic activity analysis. Citral, linalool, thymol and terpinenes were the major components in the EOs of M. officinalis, L. angustifolia and O. onites. In Ames assay, it was determined that the EO of M. officinalis had strong antimutagenic effects at all concentrations except for the highest concentrations on Salmonella typhimurium TA98 and 100 strains. L. angus-tifolia EO showed moderate antimutagenic activity against the Sodium azide (NaN3) mutagen, and reduced mutant colonies with 25.40% inhibition effect in the S. typhimurium TA100 strain at only 0.1 mu l/plate concentration. Further-more, L. angustifolia EO indicated strong antimutagenic activity against both 4-Nitro-o-phenylendiamine (NPD) and NaN3 mutagens in the S. typhimurium TA98 and 100 strains at 0.5 and 1 mu l/plate concentrations. It was determined that the EO of O. onites had a moderate antimutagenic effect at the lowest concentration and a strong antimutagenic effect at all other concentrations on S. typhimurium TA98 strain. The 0.01, 0.05 and 0.1 mu l/plate concentrations of EO of O. onites showed strong antimutagenic effect against S. typhimurium TA100 strain. The present study demonstrated that EOs of M. officinalis, L. angustifolia and O. onites possesses antimutagenic activity on the S. ty-phimurium TA98 and 100 strains.en_US
dc.identifier.doi10.7546/CRABS.2023.02.03
dc.identifier.endpage202en_US
dc.identifier.issn1310-1331
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85151909868en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage192en_US
dc.identifier.urihttps://doi.org/10.7546/CRABS.2023.02.03
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13699
dc.identifier.volume76en_US
dc.identifier.wosWOS:000981609400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPubl House Bulgarian Acad Scien_US
dc.relation.ispartofComptes Rendus De L Academie Bulgare Des Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmedicinal plantsen_US
dc.subjectantimutagenic activityen_US
dc.subjectSalmonella ty-phimuriumen_US
dc.subjectChemical-Compositionen_US
dc.subjectL.en_US
dc.titleCharacterization of essential oils from medicinal plants and assessment of their antimutagenic effects using Ames salmonella/microsomal testen_US
dc.typeArticleen_US

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