Elastic properties of the ascending aorta and left ventricular function in patients with hypothyroidism

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dc.contributor.authorÖzhan, Hakan
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorErbilen, Enver
dc.contributor.authorBulur, Serkan
dc.contributor.authorAkdemir, Ramazan
dc.contributor.authorUyan, Cihangir
dc.date.accessioned2020-05-01T09:12:10Z
dc.date.available2020-05-01T09:12:10Z
dc.date.issued2005
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000231723900004en_US
dc.descriptionPubMed: 16174118en_US
dc.description.abstractBackground: We sought to clarify the possible role of elastic properties of the ascending aorta in the development of cardiac disease associated with hypothyroidism (HT). Methods: A total of 37 patients with HT (age: 39.3 +/- 8.9years) and 29 control subjects were studied. AscendingAortic (Ao) diameter, Ao elastic indexes, strain (AoST), distensibility (AoD), stiffness index (AoSI), and pressure strain modulus were calculated from the echocardiographically derived Ao diameters. Myocardial performance index (MPI), E/A ratio, isovolumetric relaxation time (IVRT), deceleration time (DT) were measured by Doppler echocardiography to assess diastolic LV function. Patients were treated with levothyroxine and followed-up for 6 months. Thyroid function tests and echocardiographic measurement's were repeated at the end of the study. Results: AoD (cm(2) dyn(-1) 10(-3)) and AoST (%) were significantly lower (3.8 vs. 6.1; P < 0.001, 7.4 vs. 12.6, P < 0.001; respectively), whereas AoSI was higher in HT patients (6.2 vs. 3.3; P < 0.001). After treatment, AoD and AoST were increased (5.7; P < 0.001 and 11.8; P < 0. 001; respectively), whereas AoSI was decreased significantly (3.7; P < 0. 001). Also, early / late mitral peak velocity ratio (Emax/Amax) was significantly lower in HT patients (1.19 vs 1.34; P < 0.001), whereas MPI was higher (0.52 vs. 0.42; P < 0.001). MPI showed a strong correlation with aortic root indexes [AoST (r = -0.61/P < 0.001); AoD, (r = -0.57/P < 0.002); AoSI, (r = 0.531P < 0.005)] in the HT group. After 6 months of therapy, MPI significantly decreased P < 0.001) and EIA ratios were normalized (P < 0.001). Conclusions: Ao root functions have an important role on diastolic LV function. Levothyroxine replacement therapy can reverse all of these adverse effects of HT.en_US
dc.identifier.doi10.1111/j.0742-2822.2005.00189.xen_US
dc.identifier.endpage656en_US
dc.identifier.issn0742-2822
dc.identifier.issue8en_US
dc.identifier.startpage649en_US
dc.identifier.urihttps://doi.org/10.1111/j.0742-2822.2005.00189.x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5898
dc.identifier.volume22en_US
dc.identifier.wosWOS:000231723900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofEchocardiography-A Journal Of Cardiovascular Ultrasound And Allied Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaortaen_US
dc.subjectleft ventricular functionen_US
dc.subjectechocardiographyen_US
dc.titleElastic properties of the ascending aorta and left ventricular function in patients with hypothyroidismen_US
dc.typeArticleen_US

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