True empty follicle syndrome is a subtype of oocyte maturation abnormalities

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dc.contributor.authorHatirnaz, Safak
dc.contributor.authorHatirnaz, Ebru Saynur
dc.contributor.authorTan, Justin
dc.contributor.authorÇelik, Samettin
dc.contributor.authorSoyer Calıskan, Canan
dc.contributor.authorBaşbuǧ, Alper
dc.contributor.authorAydin, Gercek
dc.date.accessioned2025-10-11T20:45:32Z
dc.date.available2025-10-11T20:45:32Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: To review the outcomes of in vitro maturation (IVM) and in vitro fertilization (IVF) in women with empty follicle syndrome (EFS). The study evaluated the genetic underpinnings of EFS by analyzing mutations. Materials and Methods: This retrospective case series involving 17 women with EFS over at least 2 IVF cycles was conducted. The study also employed whole-exome sequencing to analyze the genetic mutations. The treatment approaches included letrozole-primed IVM, follicle-stimulating hormone (FSH)-human chorionic gonadotrophin (hCG)-primed IVM, and conventional IVF. Results: The average female age was 31.5±4.6 years, and the duration of infertility was 7.3±3.5 years. Four patients underwent IVF. IVM oocyte collections yielded oocytes in 12 of 13 subjects. Of these, 75% (9/12) yielded MII oocytes after 48 h of IVM media incubation. Six subjects had fertilized embryos, resulting in a 40.9% intracytoplasmic sperm injection (ICSI) fertilization rate (9 embryos/22 MII oocytes). Genetic analysis revealed mutations in seven patients. This study demonstrated the partial efficacy of letrozole-primed IVM plus growth hormone and FSH-hCG primed IVM protocols. No pregnancies or live births were recorded after IVM. One ongoing pregnancy post-IVF and one spontaneous live birth were observed. Conclusion: Inter-cycle variabilities were observed in women with oocyte maturation abnormalities (OMAs). Almost all patients with EFS had oocytes collected during IVM following IVF. These oocytes have limited potential for maturation, fertilization, and live birth, as demonstrated by the low rates observed after IVM culture and ICSI. These conditions are observed in OMAs due to defects in the oocyte machinery. The proposed flowchart provides a comprehensive classification approach for various forms of EFS. © 2024 Elsevier B.V., All rights reserved.en_US
dc.identifier.doi10.4274/tjod.galenos.2024.84031
dc.identifier.endpage152en_US
dc.identifier.issn2149-9330
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85203682727en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage142en_US
dc.identifier.trdizinid1317808en_US
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2024.84031
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1317808
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21416
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTurkish Society of Obstetrics and Gynecologyen_US
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_Scopus_20250911
dc.subjectEmpty Follicle Syndromeen_US
dc.subjectIn Vitro Maturationen_US
dc.subjectOocyte Maturation Abnormalitiesen_US
dc.subjectOocyte Maturation Arresten_US
dc.subjectChorionic Gonadotropinen_US
dc.subjectEstradiol Valerateen_US
dc.subjectFollitropinen_US
dc.subjectGrowth Hormoneen_US
dc.subjectHuman Growth Hormoneen_US
dc.subjectLetrozoleen_US
dc.subjectProgesteroneen_US
dc.subjectTestosteroneen_US
dc.subjectThyrotropinen_US
dc.subjectKocak Farmaen_US
dc.subjectQiacube Hten_US
dc.subjectQiampen_US
dc.subjectQiaseq Index I Set A Kiten_US
dc.subjectSpss Statistics Version 21.0en_US
dc.subjectChorionic Gonadotropinen_US
dc.subjectEstradiol Valerateen_US
dc.subjectFollitropinen_US
dc.subjectGrowth Hormoneen_US
dc.subjectHuman Growth Hormoneen_US
dc.subjectKocak Farmaen_US
dc.subjectLetrozoleen_US
dc.subjectProgesteroneen_US
dc.subjectTestosteroneen_US
dc.subjectThyrotropinen_US
dc.subjectAdulten_US
dc.subjectArticleen_US
dc.subjectBlastocysten_US
dc.subjectClinical Articleen_US
dc.subjectDna Extractionen_US
dc.subjectEmbryo Transferen_US
dc.subjectEmpty Follicle Syndromeen_US
dc.subjectEndometrial Thicknessen_US
dc.subjectFemaleen_US
dc.subjectFemale Infertilityen_US
dc.subjectFertilizationen_US
dc.subjectGene Mutationen_US
dc.subjectGenetic Analysisen_US
dc.subjectGestational Ageen_US
dc.subjectGestational Sacen_US
dc.subjectGynecologic Diseaseen_US
dc.subjectHumanen_US
dc.subjectIn Vitro Fertilizationen_US
dc.subjectIn Vitro Oocyte Maturationen_US
dc.subjectIntracytoplasmic Sperm Injectionen_US
dc.subjectLive Birthen_US
dc.subjectLuteal Phaseen_US
dc.subjectMenstrual Cycleen_US
dc.subjectOocyteen_US
dc.subjectOocyte Maturationen_US
dc.subjectOocyte Retrievalen_US
dc.subjectOocyte Vitrificationen_US
dc.subjectRetrospective Studyen_US
dc.subjectSpontaneous Abortionen_US
dc.subjectTransvaginal Echographyen_US
dc.subjectWhole Exome Sequencingen_US
dc.subjectYoung Adulten_US
dc.titleTrue empty follicle syndrome is a subtype of oocyte maturation abnormalitiesen_US
dc.title.alternativeGerçek boş folikül sendromu oosit olgunlaşma anomalilerinin bir alt türüdüren_US
dc.typeArticleen_US

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