Diversity of MHC class II DRB alleles in the Northern chamois genus Rupicapra

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dc.authoridAmbarlı, Hüseyin/0000-0003-4336-9417en_US
dc.authoridSafner, Toni/0000-0001-8645-5273en_US
dc.authoridFarkas, Attila/0000-0002-8995-557Xen_US
dc.authoridArnal, Maria Cruz/0000-0002-6770-3400en_US
dc.authoridBabaev, Elmar/0000-0002-2250-5267en_US
dc.authoridBego, Ferdinand/0000-0002-3975-5959en_US
dc.authoridStipoljev, Suncica/0000-0003-4635-6777en_US
dc.authorscopusid57204435538en_US
dc.authorscopusid16028076100en_US
dc.authorscopusid15061284300en_US
dc.authorscopusid14018523200en_US
dc.authorscopusid57194265477en_US
dc.authorscopusid14031587700en_US
dc.authorscopusid8212222200en_US
dc.authorwosidAmbarlı, Hüseyin/ACE-6900-2022en_US
dc.authorwosidSafner, Toni/HTM-5223-2023en_US
dc.authorwosidScandura, Massimo/K-7847-2012en_US
dc.authorwosidFarkas, Attila/ITT-6613-2023en_US
dc.authorwosidIacolina, Laura/P-8530-2016en_US
dc.contributor.authorStipoljev, Suncica
dc.contributor.authorBuzan, Elena
dc.contributor.authorIacolina, Laura
dc.contributor.authorSafner, Toni
dc.contributor.authorRezic, Andrea
dc.contributor.authorGalov, Ana
dc.contributor.authorKrizanovic, Kresimir
dc.date.accessioned2024-08-23T16:04:19Z
dc.date.available2024-08-23T16:04:19Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractMajor histocompatibility complex (MHC) genes are commonly used markers for monitoring adaptive genetic and evolutionary potential of species. In this study, we investigated genetic variation of the MHC class II DRB locus in the chamois genus Rupicapra by using next-generation sequencing. Sequencing of 102 samples led to the identification of 25 alleles, 11 of which are novel. The high ratio of the relative rates of nonsynonymous to synonymous mutations (dN/dS) suggests a signal of positive selection on this locus. We analyzed patterns of genetic variation within and among 2 subspecies of Northern Chamois and compared them to previously published studies using neutral markers to provide a basis for assessing the effects of demographic processes. Our analyses have shown that alleles are likely to be maintained by balancing selection in different populations with similar frequencies and that this mechanism also works in small, isolated populations that are strongly affected by genetic drift. In this study on the chamois genus Rupicapra, researchers explored genetic variation of the MHC class II DRB locus using next-generation sequencing. The research highlights a strong signal of positive selection at this locus, indicated by the high dN/dS ratio. The study also revealed that balancing selection maintains alleles across different chamois populations, including those that are small and isolated, emphasizing the evolutionary significance of this genetic mechanism. Graphical Abstracten_US
dc.description.sponsorshipCroatian Science Foundation [2016-06-5751]; Slovenian Research Agency [P6-0064]; RESBIOS European Union [872146]en_US
dc.description.sponsorshipThis study was supported by (i) the Croatian Science Foundation, project IP 2016-06-5751, DNA as evidence of distribution and vitality of endangered Balkan Chamois; (ii) the Slovenian Research Agency (programme group P6-0064); and (iii) the RESBIOS European Union's Horizon 2020 Research and Innovation Program (no. 872146).en_US
dc.identifier.doi10.1093/jmammal/gyae008
dc.identifier.endpage322en_US
dc.identifier.issn0022-2372
dc.identifier.issn1545-1542
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85190129440en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage312en_US
dc.identifier.urihttps://doi.org/10.1093/jmammal/gyae008
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14168
dc.identifier.volume105en_US
dc.identifier.wosWOS:001159351100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofJournal of Mammalogyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectallelic polymorphismen_US
dc.subjectmajor histocompatibility complexen_US
dc.subjectnext-generation sequencingen_US
dc.subjectRupicapra pyrenaicaen_US
dc.subjectRupicapra rupicapraen_US
dc.subjectMajor Histocompatibility Complexen_US
dc.subjectGenetic Driften_US
dc.subjectHabitat Fragmentationen_US
dc.subjectPopulation-Geneticsen_US
dc.subjectPyrenean Chamoisen_US
dc.subjectGlacial Refugiaen_US
dc.subjectSelectionen_US
dc.subjectConservationen_US
dc.subjectDnaen_US
dc.subjectRecombinationen_US
dc.titleDiversity of MHC class II DRB alleles in the Northern chamois genus Rupicapraen_US
dc.typeArticleen_US

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