Protective effect of resveratrol on cisplatin induced damage in rat kidney

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dc.contributor.authorKara, Özlem
dc.contributor.authorKilitci, Asuman
dc.contributor.authorDağlıoğlu, Gülçin
dc.date.accessioned2023-07-26T11:55:16Z
dc.date.available2023-07-26T11:55:16Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.description.abstractPurpose: The aim of this study was to evaluate the protective effect of resveratrol on cisplatin induced damage in rat kidney. Materials and Methods: 30 female Wistar-Albino rats were allocated to form three groups: In group 1 (control group), 1 mL of 0.9% NaCl (saline) was administered intraperitoneally for 3 days. In group 2 (cisplatin group), 7.5 mg / kg intraperitoneal cisplatin was given for 3 days. In group 3 (cisplatin + resveratrol group) 7.5 mg / kg cisplatin and 10 mg / kg resveratrol were given via intraperitoneal route. Right kidneys were surgically extirpated in all groups. Malondialdehyde (MDA) levels and activities of catalase (CAT) and superoxide dismutase (SOD) were measured in both blood and tissues. Also, toxicity markers such as vascular congestion, hemorrhage, tubule degeneration and glomerular damage were assessed by examining the slides prepared from kidney tissue with microscopy. Results: Tissue damage was significantly higher in group 2 than other groups. The MDA levels were significantly higher and the activities of SOD, and CAT were lower in group 2 than other groups. Conclusion: According to our short term findings, resveratrol might be an effective molecule to prevent the harmful effect of cisplatin in rat kidney.en_US
dc.identifier.doi10.17826/cumj.1086261
dc.identifier.endpage995en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue3en_US
dc.identifier.startpage990en_US
dc.identifier.trdizinid1122157en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.1086261
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1122157
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13035
dc.identifier.volume47en_US
dc.identifier.wosWOS:000889635700007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKilitci, Asuman
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectCisplatin; Resveratrol; Rat; Kidney; Toxicityen_US
dc.subjectInduced Oxidative Damage; Induced Nephrotoxicity; Vitamin-E; Selenium; Tissues; Stressen_US
dc.titleProtective effect of resveratrol on cisplatin induced damage in rat kidneyen_US
dc.typeArticleen_US

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