Is helicobacter pylori infection one of the actual causes of vitamin B12 deficiency?

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dc.contributor.authorAydın, Yusuf
dc.contributor.authorTütüncü, Yasemin Ateş
dc.contributor.authorCeran, Funda
dc.contributor.authorKöklü, Seyfettin
dc.contributor.authorYıldız, Mehmet
dc.contributor.authorCelbek, Gökhan
dc.date.accessioned2020-04-30T13:32:41Z
dc.date.available2020-04-30T13:32:41Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: Aim of this study is to determine Helicobacter pylori infection rate in Vitamin B12 deficiency and determine whether H.pylori infection is really actual cause of Vitamin B12 deficiency. Material and Methods: We evaluated 40 vitamin B12 deficient patients and 25 healthy subjects. Those patients did not have known cause of vitamin B12 deficiency. We performed endoscopic evaluation and pathological examination for H.pylori. We determined 50% atrophic gastritis in vitamin B12 deficient group, but we did not observe any atrophic gastritis in the control group endoscopically. Results: There were H.pylori positivity in 11/40 (27.5%) in the patients group but 16/25 (64) in the control group in pathological examination (p<0.01). Pathological examination of patient group also illustrated that 11 patients had mild atrophy in 11 (27.5%), 5 had moderate atrophy (12.5%) and 3 patient (7.5%) had severe atrophy. In contrast, 3 patients had only mild atrophy (12%) in the control group. We also found that H.pylori (-) 17/29 (58.6%) patients and H.pylori (+) 3/11 (27.3%) patients had atrophic gastritis in gastroscopic evaluation. Conclusion: Patients who have vitamin B12 deficiency had lower ratio of H.pylori in gastric mucosa. On the other hand, the patient group had higher ratio of atrophic gastritis in pathological and gastroscopic examination. H.pylori positivity had been decreased progressively with aging in patients group. H.pylori has disappeared in following years as a result of atrophy in gastric mucosa. We conluded that atrophic mucosa is not suitable for colonization of H.pylori infection. © 2011 Düzce Medical Journal.en_US
dc.identifier.endpage28en_US
dc.identifier.issn1307671X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/398
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastric atrophy; H.pylori; Vitamin B12 deficiencyen_US
dc.titleIs helicobacter pylori infection one of the actual causes of vitamin B12 deficiency?en_US
dc.title.alternativeHelikobakter pylori enfeksiyonu B12 eksikliğinin gerçekten bir nedeni midir?en_US
dc.typeArticleen_US

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