Independent prediction of metabolic syndrome by plasma fibrinogen in men, and predictors of elevated levels

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dc.contributor.authorOnat, Altan
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorErbilen, Enver
dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorKüçükdurmaz, Zekeriya
dc.contributor.authorCan, Günay
dc.contributor.authorHergenç, Gülay
dc.date.accessioned2020-04-30T23:18:29Z
dc.date.available2020-04-30T23:18:29Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000266884600013en_US
dc.descriptionPubMed: 18582961en_US
dc.description.abstractThe role of plasma fibrinogen levels in predicting metabolic syndrome (MetS) and assessment of determinants of these levels were investigated. A total of 2234 men and women, aged 49 +/- 12 years, representative of Turkish adults who had plasma fibrinogen determinations, were prospectively evaluated and followed for a mean of 6.6 years. The modified Clauss method was used for assays. MetS was defined by ATPIII criteria modified for male abdominal obesity. MetS cases at baseline were excluded in prospective analyses. Median (interquartile range) fibrinogen values were 2.87 (2.29; 3.56) g/L. Fibrinogen levels predicted significantly newly developing MetS in men (RR 1.40 [95%CI 1.07; 1.83] for a 2-fold increment), after adjustment for age and smoking status, and (RR 1.32 [95%CI 0.95; 1.83] again for doubling), after additional adjustment for all 5 components of MetS. MetS was not significantly predicted by fibrinogen levels in women in either multivariable model. By regression analysis of eight covariates, not waist circumference, but systolic blood pressure, current smoking and C-reactive protein (CRP) in men, and age in women were predictors of elevated (>3.0 g/L) fibrinogen at follow-up (p<0.05 in all). Conclusions: Plasma fibrinogen predicts MetS independently of its components in men, in contradistinction to women, and, hence, is likely one of its components. Hyperfibrinogenemia representing an inflammatory state is postulated as the underlying mechanism. Central obesity is linked to elevation in fibrinogen mainly through the mediation of blood pressure, CRP, and via being affected by cigarette smoking. Crown Copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijcard.2008.03.054en_US
dc.identifier.endpage217en_US
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.issue2en_US
dc.identifier.startpage211en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2008.03.054
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3350
dc.identifier.volume135en_US
dc.identifier.wosWOS:000266884600013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCentral obesityen_US
dc.subjectFibrinogenen_US
dc.subjectHypertensionen_US
dc.subjectInflammatory stateen_US
dc.subjectInsulin resistanceen_US
dc.subjectMetabolic syndromeen_US
dc.titleIndependent prediction of metabolic syndrome by plasma fibrinogen in men, and predictors of elevated levelsen_US
dc.typeArticleen_US

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