Cranial Magnetic Resonance Imaging as a Screening Tool for Evaluation of Silent Brain Ischemia in Severe Coronary Artery Disease: A Clinical Based Study

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dc.contributor.authorÖzçağalayan, Tuğba İlkem Kurtoğlu
dc.contributor.authorGür, Demet Özkaramanlı
dc.contributor.authorÜnal, Aysun
dc.contributor.authorÖzçağalayan, Ömer
dc.contributor.authorTopçu, Birol
dc.date.accessioned2023-04-10T20:19:38Z
dc.date.available2023-04-10T20:19:38Z
dc.date.issued2020
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: Silent brain ischemia (SBI), defined as ischemic changes and infarcts without neurologicsigns, is an established marker of poor survival. Magnetic resonance imaging (MRI) is usefulto define SBI and white matter hyperintensities that correspond to microangipathic ischemicdisease. This study aimed to investigate the relationship among SBI, white matter lesions andthe extent of coronary artery disease (CAD), and to determine possible predictors of SBI.Material and Methods: A total 10640 patients who underwent coronary angiography wereretrospectively screened to reveal 312 patients who had been evaluated with a subsequentcranial MRI within 6 months. CAD severity was established with Gensini score and MRIswere evaluated to determine presence of SBI and white matter hyperintensities scored byFazekas. Finally, 58 patients with SBI and 254 without SBI consisted SBI and non-SBI groups.Results: Patients with SBI were significantly older with higher prevalence of male gender thanthe non-SBI patients. Both Gensini and Fazekas scores were higher in SBI-group (p<0.001).Fazekas score was positively correlated with Gensini score (r=0.219, p<0.001) and age(r=0.465, p<0.001). In the logistic regression analysis; age, male gender and Gensini scorewere identified as the independent predictors of SBI.Conclusion: Although SBIs don’t present neurological symptoms they are associated withpoor survival and future stroke. Our data suggest that cranial MRI may be a screening tool inrisk stratification, particularly in elderly male patients with multivessel CAD. Our study alsodepicted that age, male gender and high Gensini scores are the independent predictors of SBI.en_US
dc.identifier.doi10.18678/dtfd.763145
dc.identifier.endpage206en_US
dc.identifier.issn1307-671X
dc.identifier.issue3en_US
dc.identifier.startpage201en_US
dc.identifier.trdizinid442626en_US
dc.identifier.urihttp://doi.org/10.18678/dtfd.763145
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/442626
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11451
dc.identifier.volume22en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleCranial Magnetic Resonance Imaging as a Screening Tool for Evaluation of Silent Brain Ischemia in Severe Coronary Artery Disease: A Clinical Based Studyen_US
dc.typeArticleen_US

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