Prognostic Importance of PD-L1 Expression in Breast Carcinomas

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dc.authoridAkpinar, Reha/0000-0002-6444-0932en_US
dc.authorscopusid57190868927en_US
dc.authorscopusid36552264900en_US
dc.authorscopusid6603003841en_US
dc.authorwosidAkpinar, Reha/HSH-4132-2023en_US
dc.contributor.authorAkpinar, Reha
dc.contributor.authorDemir, Hale
dc.contributor.authorIlvan, Sennur
dc.date.accessioned2024-08-23T16:03:24Z
dc.date.available2024-08-23T16:03:24Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractOBJECTIVE Breast carcinoma (BC) is the most common cancer in women, and, in particular, some subtypes are established as suitable for immunotherapy strategies targeting immune checkpoints. Programmed cell death-1 (PD-1), as well as cytotoxic T lymphocyte-associated protein-4 (CTLA-4), has an important role in the tumor microenvironment to escape from the immune system. In this study, we examined the relationship of Programmed cell death-1 (PD-L1) expression with survival, recurrence, and other prognostic factors. METHODS This retrospective cohort comprised tissue microarray blocks of 391 cases examined at the same institute between 2000-2012. All cases were completely resected tumors, without neoadjuvant therapy, with more than 5 years of follow-up. Clinical follow-up and all pathologic parameters were recorded. PD-L1 immunohistochemistry (SP263) was applied, then staining details including density, percentage, and patterns were noted for tumor areas and immune cells. PD-L1 expression results were analyzed, and its relationship with prognostic parameters and survival was investigated. RESULTS PD-L1 expression was detected in 90 (24.8%) cases: 55 in only tumor-infiltrating lymphocytes (TILs), 35 in both tumor and TILs. Statistically, there was no significant relationship between PD-L1 expression and survival. However, high histologic grade, high scores in pleomorphism and mitosis, mild stromal reaction, dense immune cell infiltration, perineural invasion, absence of lymph node metastasis, negativity of ER and PR, HER2 expression, and high Ki -67 results had a significant relationship with PD-L1 expression. CONCLUSION Consistent with the literature, our results showed that PD-L1 expression in triple-negative and HER2 overexpressed types and in the presence of TILs is higher than in other breast cancers.en_US
dc.description.sponsorshipIstanbul University (IU-BAP) [TTU-2018-30597]en_US
dc.description.sponsorshipFinancial Support: This study has been supported by Istanbul University (IU-BAP no: TTU-2018-30597) .en_US
dc.identifier.doi10.5505/tjo.2024.4254
dc.identifier.endpage166en_US
dc.identifier.issn1300-7467
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85196386523en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.5505/tjo.2024.4254
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13724
dc.identifier.volume39en_US
dc.identifier.wosWOS:001186141100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast carcinomaen_US
dc.subjectimmunotherapyen_US
dc.subjectPD-L1en_US
dc.subjecttumor-infiltrating lymphocytes.en_US
dc.subjectTumor-Infiltrating Lymphocytesen_US
dc.subjectLigand 1 Pd-L1en_US
dc.subjectImmune Checkpointsen_US
dc.subjectCanceren_US
dc.subjectBlockadeen_US
dc.subjectTilsen_US
dc.titlePrognostic Importance of PD-L1 Expression in Breast Carcinomasen_US
dc.typeArticleen_US

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