Fatal neutropenic enterocolitis following methotrexate overdose: A case report

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dc.contributor.authorİnce, Nevin
dc.contributor.authorTunca, Bekir
dc.contributor.authorYekenkurul, Dilek
dc.contributor.authorYıldırım, Mustafa
dc.date.accessioned2020-04-30T13:32:29Z
dc.date.available2020-04-30T13:32:29Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractMethotrexate, a folic acid antagonist, is widely used in the treatment of neoplasms in addition to diseases such as psoriasis and rheumatoid arthritis. Although well tolerated under normal conditions, the use of more than the recommended doses may cause life-threatening toxicities. Toxicity due to high doses of methotrexate is manifested by bone marrow inhibition, gastrointestinal mucosal damage and pancytopenia. Most cases result from overdose. However, serious adverse events that result in mortality, in particular those of mixing medication in elderly patients, are rare. Herein, we present the case of a 72-year-old man who admitted to the emergency department with painful oral ulcers, inability to swallow and a general impaired condition, and died of sepsis after developing neutropenic enterocolitis following a fever and neutropenia. © 2019, Duzce University Medical School. All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.639211en_US
dc.identifier.endpage262en_US
dc.identifier.issn1307671X
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage260en_US
dc.identifier.urihttps://dx.doi.org/10.18678/dtfd.639211
dc.identifier.urihttps://hdl.handle.net/20.500.12684/317
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMethotrexate; Neutropenic enterocolitis; Overdose; Pancytopeniaen_US
dc.titleFatal neutropenic enterocolitis following methotrexate overdose: A case reporten_US
dc.title.alternativeYüksek doz metotreksat alımı sonrası gelişen fatal nötropenik enterokolit: Olgu sunumuen_US
dc.typeArticleen_US

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