EVALUATION OF ATHEROSCLEROTIC RISK FACTORS AND CAROTID INTIMA MEDIA THICKNESS IN HEALTHY OFFSPRING OF TYPE 2 DIABETIC PATIENTS

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dc.contributor.authorÜstün, I.
dc.contributor.authorAydın, Y.
dc.contributor.authorArduç, A.
dc.contributor.authorBerker, D.
dc.contributor.authorÖzoğuz, Ufuk
dc.contributor.authorYulmaz, M.
dc.contributor.authorÜnlü, E.
dc.date.accessioned2020-05-01T12:11:56Z
dc.date.available2020-05-01T12:11:56Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionUstun, Ihsan/0000-0002-5848-1586en_US
dc.descriptionWOS: 000287017600008en_US
dc.description.abstractAim is to evaluate atherosclerotic risk factors and carotid intima media thickness [CIMT] in offspring of type 2 Diabetes Mellitus [DM] patients with normal glucose tolerance. Methods. We evaluated 96 offspring of Type 2 DM patients and 39 healthy control who were in similar age, sex and body mass. We measured fasting blood glucose [FBG], postprandial blood glucose [PBG], insulin, uric acid, homocystein, fibrinogen, HOMA-IR, lipid profile, hsCRP, microalbuminuria, glycosylated hemoglobin A1c and CIMT by Doppler ultrasonography. Results. FBG was found higher in study group [p<0.001]. The HOMA-IR was 1.7+/-0.98 and 1.2+/-0.58 mg/dL x uUI/mL for study and control group, respectively [p=0.007]. T-Cholesterol, triglycerides, HDL-C, LDL-C and homocystein levels were not different. HsCRP and fibrinogen levels were higher in study group [p=0.014 and p=0.035, respectively]. Microalbuminuria levels were higher in study group but not significant [p=0.111]. CIMT in study group increased distinctively [p<0,001]. In regression analysis, being in study group causes a significant increase on the mean CIMT level by 0.057 mm [0.029-0.086] Conclusion. Our study demonstrated that various atherosclerotic risk factors are aggregated in offspring of Type 2 DM patients having NUT even before they develop glucose intolerance. Having a diabetic family alone might be effective in developing increased CIMT.en_US
dc.identifier.doi10.4183/aeb.2010.211en_US
dc.identifier.endpage227en_US
dc.identifier.issn1841-0987
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage211en_US
dc.identifier.urihttps://doi.org/10.4183/aeb.2010.211
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6295
dc.identifier.volume6en_US
dc.identifier.wosWOS:000287017600008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEditura Acad Romaneen_US
dc.relation.ispartofActa Endocrinologica-Bucharesten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectcarotid intima media thicknessen_US
dc.subjectoffspringen_US
dc.subjectdiabetes mellitusen_US
dc.titleEVALUATION OF ATHEROSCLEROTIC RISK FACTORS AND CAROTID INTIMA MEDIA THICKNESS IN HEALTHY OFFSPRING OF TYPE 2 DIABETIC PATIENTSen_US
dc.typeArticleen_US

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