Cytotoxic and Genotoxic Effects of Sulfonamide-Aldehyde Derivative in Allium cepa Root Tip Cells

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dc.contributor.authorGümüş, Nisa
dc.contributor.authorGümüş, Mehmet
dc.contributor.authorYağcı, Emre
dc.contributor.authorEroğlu, Halil Erhan
dc.contributor.authorKoca, İrfan
dc.date.accessioned2023-04-10T20:25:54Z
dc.date.available2023-04-10T20:25:54Z
dc.date.issued2021
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractThe continuous production and release into the environment of chemicals has revealed the need to determine their cytotoxicity and genotoxicity. Sulfonamide-aldehyde (SA) derivatives, whose biological activity properties vary in a wide spectrum, are frequently used in agriculture, medicine, pharmacy and many other fields. These compounds have an important cycle in the ecological system due to their use and diversity. In the present study, the potential cytotoxic and genotoxic effects of sulfonamide-aldehyde derivative were investigated using Allium test system with the concentrations of 6.25, 12.5, 25, 50, and 100 µM. In A. cepa cells, the increasing concentrations of SA caused cytotoxic effects by inducing nuclear lesions and inhibition of mitotic index. In addition, the increasing concentrations of SA caused genotoxic effects by inducing micronucleus and chromosome aberrations, which the most common ones are C-mitosis, sticky metaphase, and anaphase bridge. The results indicate that the concentration of 25 µM is $EC_{50}$ in micronucleus, nuclear lesions, and chromosome aberrations; and 50 µM is EC50 in mitotic index (p < 0.05)en_US
dc.identifier.doi10.29130/dubited.752287
dc.identifier.endpage138en_US
dc.identifier.issn2148-2446
dc.identifier.issue1en_US
dc.identifier.startpage130en_US
dc.identifier.trdizinid496531en_US
dc.identifier.urihttp://doi.org/10.29130/dubited.752287
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/496531
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11693
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Üniversitesi Bilim ve Teknoloji Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleCytotoxic and Genotoxic Effects of Sulfonamide-Aldehyde Derivative in Allium cepa Root Tip Cellsen_US
dc.typeArticleen_US

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