Effects of europinidin-o-methylated anthocyanidin on scopolamine-induced memory impairments by improving neurological expression: An integrated with insilico and ADMET properties by computational analysis

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dc.authoridGuven, Emine/0000-0001-9324-0879;
dc.contributor.authorAnsari, Mohamamd Anas
dc.contributor.authorImam, Faisal
dc.contributor.authorAl-Harbi, Naif O.
dc.contributor.authorGuven, Emine
dc.contributor.authorAlam, Md Sohrab
dc.contributor.authorAhmad, Md Maaz
dc.contributor.authorSyed, Shoaeb Mohammad
dc.date.accessioned2025-10-11T20:48:32Z
dc.date.available2025-10-11T20:48:32Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThis research aimed to determine if europinidin-o-methylated anthocyanidin could protect rats from memory and learning impairments induced by scopolamine (SCOP). The experiment involved four groups of Wistar rats with normal control, SCOP-treated group, europinidin (10 mg/kg and 20 mg/kg p.o.) for 14-day. After that, assessments of movement, memory recall, and learning were conducted. Brain tissue was analyzed for various markers, namely choline acetyltransferase (ChAT), acetylcholine esterase (AChE), antioxidants, nitrites, antiinflammatory, and brain-derived neurotrophic factor (BDNF). SCOP significantly impaired memory and altered brain chemistry. Europinidin treatment, however, reversed these effects, improving neurobehavioral function, reducing oxidative stress and inflammation, and restoring AChE, ChAT, and BDNF levels. Docking studies further revealed europinidin's favourable interaction with ChAT, supporting its protective mechanism. Europinidin showed favorable affinity towards ChAT with docking scores of-8.77 kcal/mol. The study demonstrates europinidin effectiveness in mitigating SCOP-induced memory deficits among rats.en_US
dc.description.sponsorshipKing Saud University, Riyadh, Saudi Arabia [ORF-2025-939]en_US
dc.description.sponsorshipThe authors are thankful to the Ongoing Research Funding Program (ORF-2025-939), King Saud University, Riyadh, Saudi Arabia for financial support.en_US
dc.identifier.doi10.1016/j.lmot.2025.102161
dc.identifier.issn0023-9690
dc.identifier.issn1095-9122
dc.identifier.scopus2-s2.0-105010139104en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.lmot.2025.102161
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21954
dc.identifier.volume91en_US
dc.identifier.wosWOS:001537582500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofLearningand Motivationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectAcetylcholinesteraseen_US
dc.subjectCholine acetyltransferaseen_US
dc.subjectMemory deficiencyen_US
dc.subjectNeurodegenerationen_US
dc.subjectNeuroprotectiveen_US
dc.titleEffects of europinidin-o-methylated anthocyanidin on scopolamine-induced memory impairments by improving neurological expression: An integrated with insilico and ADMET properties by computational analysisen_US
dc.typeArticleen_US

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