Efficacy of Transarterial Chemoembolization with Drug-Eluting Beads in Hepatocellular Carcinoma: A Single-Center Experience

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dc.contributor.authorDanışan, Gürkan
dc.contributor.authorArık, Erbil
dc.date.accessioned2023-04-10T20:20:59Z
dc.date.available2023-04-10T20:20:59Z
dc.date.issued2022
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: The aim of this study was to evaluate the efficacy of transarterial chemoembolization (TACE) with drug-eluting beads in hepatocellular carcinoma (HCC). Material and Methods: Twenty-nine patients with HCC who were treated with TACE with drug-eluting beads between 2019 and 2021 were included in the study. The success of the TACE procedure was evaluated using pre- and post-operative contrast-enhanced computed tomography/magnetic resonance images. Patient characteristics, embolizing-bead sizes, procedure-related complications, and pre- and post-procedure alpha-fetoprotein (AFP) levels were recorded. Results: The mean age of the patients was 65.6±10.4 years, and the objective response rate was 17.2% (5/29). 100-300 ?m particles were used in 11 (37.9%) patients, and 300-500 ?m particles were used in 18 (62.1%). The median target lesion number was 1 (range, 1-6). Six (20.7%) patients had non-target lesions. There were newly developed lesions in four (13.8%) patients. A significant decrease was found in the median target lesion size after (41; range, 0-116 mm) the procedure compared to the pre- (42; range, 22-188 mm) procedure (p<0.001). A significant difference was found between the median AFP levels before (343; range, 1.44-2000 ng/mL) and after (52; range, 0.95-1435 ng/mL) the procedure (p<0.001). Conclusion: Since most patients with HCC are diagnosed in the intermediate stage, curative treatment is not possible. TACE is an important treatment option for the local control of the disease in this patient group. However, the success of TACE treatment may vary depending on the cancer stage, number of patients, follow-up period, and type and size of the microsphere used.en_US
dc.identifier.doi10.18678/dtfd.1075822
dc.identifier.endpage109en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.startpage105en_US
dc.identifier.trdizinid1115661en_US
dc.identifier.urihttp://doi.org/10.18678/dtfd.1075822
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1115661
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11502
dc.identifier.volume24en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject: hepatocellular carcinomaen_US
dc.subjecttransarterial chemoembolizationen_US
dc.subjectdrug-eluting beadsen_US
dc.titleEfficacy of Transarterial Chemoembolization with Drug-Eluting Beads in Hepatocellular Carcinoma: A Single-Center Experienceen_US
dc.typeArticleen_US

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