The effects of valproate and carbamazepine intake on serum leptin, insulin, lipid profiles, C-reactive protein levels and weight

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dc.contributor.authorGüzel, Ahmet
dc.contributor.authorKarasalihoğlu, Serap
dc.date.accessioned2024-12-28T20:19:52Z
dc.date.available2024-12-28T20:19:52Z
dc.date.issued2009
dc.description.abstractObjectives: This study aims to evaluate the effects of valproate (VPA) and carbamazepine (CBZ) intake onserum leptin, insulin, lipid profiles, C-reactive protein (CRP) levels, C-peptid and weight.Patients and methods: Twenty-nine using VPA (Group I), and 21 patients using CBZ (Group II) aged 1.5-15years and 35 healthy children (Group III) were included.Results: The rates of weight intake according to body mass index percentile increaase were 6.9 %, (2 cases) inthe Group I and 19 % (4 cases) in the Group II. In Group II, levels of only LDL-K and TK were significantlyhigher than in Group I, but increasing of these lipids were not statistically significant compared with the controlgroup. However, no significant effect of serum levels of leptin, insulin, lipid profile, CRP, and C-peptide wereobserved on weight intake.Conclusion: The etiology of weight gain due to VPA and CBZ intake was not associated with hyperleptinemia,hyperinsulinemia and hyperlipidemia. Multifactorial associations among heredity, socioeconomic factors,dietary habits, enviromental factors and family education should be taken into consideration in the etiology ofweight gain secondary to antiepileptics. Further new studies about this subject should be performed.
dc.description.abstractObjectives: This study aims to evaluate the effects of valproate (VPA) and carbamazepine (CBZ) intake on serum leptin, insulin, lipid profiles, C-reactive protein (CRP) levels, C-peptid and weight. Patients and methods: Twenty-nine using VPA (Group I), and 21 patients using CBZ (Group II) aged 1.5-15 years and 35 healthy children (Group III) were included. Results: The rates of weight intake according to body mass index percentile increaase were 6.9 %, (2 cases) in the Group I and 19 % (4 cases) in the Group II. In Group II, levels of only LDL-K and TK were significantly higher than in Group I, but increasing of these lipids were not statistically significant compared with the control group. However, no significant effect of serum levels of leptin, insulin, lipid profile, CRP, and C-peptide were observed on weight intake. Conclusion: The etiology of weight gain due to VPA and CBZ intake was not associated with hyperleptinemia, hyperinsulinemia and hyperlipidemia. Multifactorial associations among heredity, socioeconomic factors, dietary habits, enviromental factors and family education should be taken into consideration in the etiology of weight gain secondary to antiepileptics. Further new studies about this subject should be performed
dc.identifier.dergiparkDergiPark: 611013
dc.identifier.endpage20
dc.identifier.issn1307-671X
dc.identifier.issue1
dc.identifier.startpage13
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/793260
dc.identifier.urihttps://dergipark.org.tr/tr/pub/dtfd/issue/48266/611013
dc.identifier.urihttps://hdl.handle.net/20.500.12684/16266
dc.identifier.volume11
dc.language.isotr
dc.publisherDüzce Üniversitesi
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241228
dc.subjectValproic acid
dc.subjectcarbamazepine
dc.subjectobesity
dc.subjectleptin
dc.subjectinsulin
dc.subjectValproic acid
dc.subjectcarbamazepine
dc.subjectobesity
dc.subjectleptin
dc.subjectinsulin
dc.titleThe effects of valproate and carbamazepine intake on serum leptin, insulin, lipid profiles, C-reactive protein levels and weight
dc.title.alternativeThe effects of valproate and carbamazepine intake on serum leptin, insulin, lipid profiles, C-reactive protein levels and weight
dc.typeArticle

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