Can the gastrointestinal system alter liver damage caused by COVID-19?

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dc.authorscopusid57218169335en_US
dc.authorscopusid7006702494en_US
dc.contributor.authorÖzkan, K.
dc.contributor.authorDemir, Ş.
dc.date.accessioned2024-08-23T16:07:22Z
dc.date.available2024-08-23T16:07:22Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractOur gastrointestinal system, often referred to as our "second brain," is grappling with the devastating effects of COVID-19, a disease that has plagued recent years. Researchers are investigating how bacteria in the intestinal microflora may contribute to or mitigate liver damage caused by COVID-19. Despite the limited number of studies, the fight against liver organ damage by the gastrointestinal system, which is our second brain is important. All original articles published in English until March 01, 2020, were retrieved via a library-assisted literature search from PubMed/MEDLINE, Excerpta Medica Database (EMBASE), and Web of Science. A total of nine articles (2.188 patients) were found eligible for inclusion. Effect size and 95% confidence interval were evaluated in this study. The randomized trials exhibit a noteworthy level of heterogeneity (p<0.05), and upon scrutinizing the funnel plot, there is no discernible indication of publication bias. According to the meta-analysis tree graph, the weights of the studies are significantly to the right of the 2 vertical lines. The confidence interval of each study has significant weights. According to the study findings, the interaction of the intestinal flora and the immune system showed us that there is an area that we need to investigate against the COVID-19 disease. For many years, research has tried to explain how the signaling pathways in the intestinal tract are related to the brain. The study revealed that our digestive system plays a crucial role as an auxiliary component of our brain. Future studies should uncover the main ways of this communication. © 2024 Ondokuz Mayis Universitesi. All rights reserved.en_US
dc.identifier.doi10.52142/omujecm.41.2.29
dc.identifier.endpage406en_US
dc.identifier.issn1309-4483
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85197660116en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage397en_US
dc.identifier.urihttps://doi.org/10.52142/omujecm.41.2.29
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14625
dc.identifier.volume41en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOVID-19 and microbiomeen_US
dc.subjectCOVID-19 liver effecten_US
dc.subjectgut brain axisen_US
dc.subjectsecond brainen_US
dc.subjectbrain-gut axisen_US
dc.subjectcomorbidityen_US
dc.subjectcoronavirus disease 2019en_US
dc.subjectdisease associationen_US
dc.subjecteffect sizeen_US
dc.subjectEmbaseen_US
dc.subjectgastrointestinal tracten_US
dc.subjecthumanen_US
dc.subjectimmune systemen_US
dc.subjectintestine floraen_US
dc.subjectliver injuryen_US
dc.subjectMedlineen_US
dc.subjectmeta analysisen_US
dc.subjectnonhumanen_US
dc.subjectpublication biasen_US
dc.subjectrandomized controlled trial (topic)en_US
dc.subjectReviewen_US
dc.subjectsystematic reviewen_US
dc.subjectWeb of Scienceen_US
dc.titleCan the gastrointestinal system alter liver damage caused by COVID-19?en_US
dc.typeReviewen_US

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