Can the gastrointestinal system alter liver damage caused by COVID-19?
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ondokuz Mayis Universitesi
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Our gastrointestinal system, often referred to as our "second brain," is grappling with the devastating effects of COVID-19, a disease that has plagued recent years. Researchers are investigating how bacteria in the intestinal microflora may contribute to or mitigate liver damage caused by COVID-19. Despite the limited number of studies, the fight against liver organ damage by the gastrointestinal system, which is our second brain is important. All original articles published in English until March 01, 2020, were retrieved via a library-assisted literature search from PubMed/MEDLINE, Excerpta Medica Database (EMBASE), and Web of Science. A total of nine articles (2.188 patients) were found eligible for inclusion. Effect size and 95% confidence interval were evaluated in this study. The randomized trials exhibit a noteworthy level of heterogeneity (p<0.05), and upon scrutinizing the funnel plot, there is no discernible indication of publication bias. According to the meta-analysis tree graph, the weights of the studies are significantly to the right of the 2 vertical lines. The confidence interval of each study has significant weights. According to the study findings, the interaction of the intestinal flora and the immune system showed us that there is an area that we need to investigate against the COVID-19 disease. For many years, research has tried to explain how the signaling pathways in the intestinal tract are related to the brain. The study revealed that our digestive system plays a crucial role as an auxiliary component of our brain. Future studies should uncover the main ways of this communication. © 2024 Ondokuz Mayis Universitesi. All rights reserved.
Açıklama
Anahtar Kelimeler
COVID-19 and microbiome, COVID-19 liver effect, gut brain axis, second brain, brain-gut axis, comorbidity, coronavirus disease 2019, disease association, effect size, Embase, gastrointestinal tract, human, immune system, intestine flora, liver injury, Medline, meta analysis, nonhuman, publication bias, randomized controlled trial (topic), Review, systematic review, Web of Science
Kaynak
Journal of Experimental and Clinical Medicine (Turkey)
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
41
Sayı
2
