The effect of astaxanthin on amiodarone induced cardiac tissue damage in rat

Basit Öğe Kaydı
dc.authoridKara, Ozlem/0000-0002-2084-8290en_US
dc.authorwosidkara, ozlem/JLK-9539-2023en_US
dc.contributor.authorKara, Ozlem
dc.contributor.authorKilitci, Asuman
dc.date.accessioned2024-08-23T16:03:52Z
dc.date.available2024-08-23T16:03:52Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to evaluate the effect of astaxanthin on amiodarone induced cardiac tissue damage.Materials and Methods: 3 groups were formed using 30 Wistar albino rats. In group 1 (control group) (n=10), neither any drugs were given nor anything was performed. In group 2 (amiodarone group) (n=10), 100 mg/kg amiodarone was given for 7 days. In group 3 (amiodarone+astaxanthin group) (n=10), 100 mg/kg amiodarone and 25 mg/kg astaxanthin were given for 7 days. Hearts were surgically extirpated in all groups. Blood malondialdehyde (MDA) levels and activities of catalase (CAT) and superoxide dismutase (SOD) were measured. Also, toxicity markers such as edema, hemorrhage, fibrosis, inflammatory cell infiltration were assessed by examining the slides prepared from cardiac tissue with microscopy.Results: The MDA levels were significantly higher and the activities of SOD, and CAT were lower in group 2 than group 3. Tissue damage was significantly higher in group 2 than group 3.Conclusion: According to our short term findings, astaxanthin reversed the toxicity of amiodarone on cardiac tissue. In the light of these promising results, we suggest that astaxanthin usage should be thought to protect the cardiac damage due to amiodarone.en_US
dc.identifier.doi10.17826/cumj.1224847
dc.identifier.endpage199en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue1en_US
dc.identifier.startpage194en_US
dc.identifier.trdizinid1181515en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.1224847
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1181515
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13962
dc.identifier.volume48en_US
dc.identifier.wosWOS:000960019300023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmiodaroneen_US
dc.subjectastaxanthinen_US
dc.subjectraten_US
dc.subjectcardiac tissueen_US
dc.subjecttoxicityen_US
dc.subjectCisplatin-Induced Damageen_US
dc.subjectToxicityen_US
dc.subjectResveratrolen_US
dc.subjectAgeen_US
dc.titleThe effect of astaxanthin on amiodarone induced cardiac tissue damage in raten_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
13962.pdf
Boyut:
322.86 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu