Protective Effects of Origanum onites and Its Components on Lead-Nitrate Induced Genotoxicity in Root Cells of Allium cepa L.

Basit Öğe Kaydı
dc.authoridugras, serpil/0000-0002-1867-5781en_US
dc.authorscopusid54397548800en_US
dc.authorscopusid57211937014en_US
dc.authorscopusid58899514500en_US
dc.authorscopusid57193210810en_US
dc.authorscopusid6507373295en_US
dc.authorwosidugras, serpil/KSM-3256-2024en_US
dc.contributor.authorUgras, Serpil
dc.contributor.authorRasgele, Pinar Goc
dc.contributor.authorTemizce, Semih
dc.contributor.authorEmire, Zuhal
dc.contributor.authorDirmenci, Tuncay
dc.date.accessioned2024-08-23T16:03:42Z
dc.date.available2024-08-23T16:03:42Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThis study investigates the protective effects of components (Thymol; Thy, Carvacrol; Car, Linalool; Lin, and alpha-Pinene; AP) and essential oil of Origanum onites L. (O. onites-EO), against lead nitrate -induced cytotoxicity and genotoxicity in Allium cepa L. (A. cepa) root tip cells. These components obtained from O. onites were characterized by gas chromatography (GC). A. cepa bulbs were exposed to 6.25-12.5 mg/L concentrations of the O. onites-EO/components of O. onites-EO for analyses of induction of cytogenetic damage. Then, these bulbs were exposed to 10 mg/L concentrations of lead nitrate for analyses of the protective effects of O. onites and its components. Mitotic abnormalities were evaluated for genotoxicity, and mitotic index (MI) for cytotoxicity. As a result of this study, lead nitrate increased the total chromosomal abnormality amount in A. cepa, indicating genotoxicity. MI was decreased with lead nitrate. However, this effect was significantly improved by components of O. onites-EO. This effect was shown with the decrease in the number of chromosomal abnormalities and increase in MI rates in lead nitrate -induced root cells after exposure to the components of O. onites-EO. The protective effect of O. onites-EO components against the damage caused by lead nitrate in cells can be listed as alpha- Pinene > Thymol > Carvacrol > Linalool. Among all essential oil components tested, alpha-Pinene was determined to have the strongest protective effect. Furthermore, the protective effect of the essential oil, which contains all the components, could not be determined. It has been observed that the components of essential oil have different effects, and it can be said that these components suppress the effects of each other in the mixture where they are found together. In conclusion, this study shows that the components of O. onites-EO have a protective effect on lead nitrate -induced A. cepa root cells.en_US
dc.identifier.doi10.25135/rnp.440.2311.2990
dc.identifier.endpage154en_US
dc.identifier.issn1307-6167
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85185696386en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.25135/rnp.440.2311.2990
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13874
dc.identifier.volume18en_US
dc.identifier.wosWOS:001157258900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcg Publicationsen_US
dc.relation.ispartofRecords of Natural Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-genotoxicityen_US
dc.subjectessential oilen_US
dc.subjectheavy metal toxicityen_US
dc.subjectlead-nitrateen_US
dc.subjectEssential Oilsen_US
dc.subjectVolatile Constituentsen_US
dc.subjectOxidative Stressen_US
dc.subjectAlpha-Pineneen_US
dc.subjectCytotoxicityen_US
dc.subjectAntioxidanten_US
dc.subjectApoptosisen_US
dc.subjectHepatotoxicityen_US
dc.subjectAntifungalen_US
dc.subjectCarvacrolen_US
dc.titleProtective Effects of Origanum onites and Its Components on Lead-Nitrate Induced Genotoxicity in Root Cells of Allium cepa L.en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu