Is Selective Head Cooling Combined with Whole-Body Cooling the Most Effective Hypothermia Method for Neonatal Hypoxic-Ischemic Encephalopathy?

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dc.authoridÇelik, Yalçın/0000-0002-1357-0585
dc.contributor.authorÇelik, Yalçın
dc.contributor.authorÖzgür, Anıl
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorYıldırım, Nazim
dc.contributor.authorTeke, Selçuk
dc.date.accessioned2023-07-26T11:54:03Z
dc.date.available2023-07-26T11:54:03Z
dc.date.issued2022
dc.departmentDÜ, Ziraat Fakültesi, Biyosistem Mühendisliği Bölümüen_US
dc.description.abstractThis study aimed to compare combined hypothermia (CH) to the 2 classical therapeutic hypothermia (TH) methods selective head cooling (SHC) and whole-body cooling (WBC). This retrospective cohort study included neonates who underwent CH, SHC, and WBC between 2012 and 2020. Mean rectal temperature was maintained at 33.5 +/- 0.5 degrees C by cooling the head and the body in the CH group, at 34.5 +/- 0.5 degrees C by cooling the head in the SHC group, and at 33.5 +/- 0.5 degrees C by cooling the body in the WBC group. The groups were compared in terms of side effects, magnetic resonance imaging (MRI) scores, and status at discharge. The study included 60 neonates in the CH group, 112 in the WBC group, and 27 in the SHC group. There was no significant difference in side effects between the groups (p > 0.05). There was no significant difference in brain MRI scores between the groups (p > 0.05); however, gray matter, white matter, and total MRI scores in the CH group were lower than in the WBC group. Duration of hospitalization was shorter in the CH group than in the other two groups (p = 0.022). CH was not associated with more side effects than the two classical TH methods. In addition, some of these findings suggest that CH might result in better clinical outcome than the two classical TH methods.en_US
dc.identifier.doi10.1089/ther.2022.0021
dc.identifier.issn2153-7658
dc.identifier.issn2153-7933
dc.identifier.pmid36251965en_US
dc.identifier.urihttps://doi.org/10.1089/ther.2022.0021
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12707
dc.identifier.wosWOS:000870497000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSungur, Mehmet Ali
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofTherapeutic Hypothermia and Temperature Managementen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectHypoxic-Ischemic Encephalopathy; Newborns; Therapeutic Hypothermia; Selective Head Cooling; Whole-Body Coolingen_US
dc.subjectTherapeutic Hypothermia; Dysfunction; Lesionsen_US
dc.titleIs Selective Head Cooling Combined with Whole-Body Cooling the Most Effective Hypothermia Method for Neonatal Hypoxic-Ischemic Encephalopathy?en_US
dc.typeArticleen_US

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