Tunable Arene Ruthenium Metallaprisms to Transport, Shield, and Release Porphin in Cancer Cells

Basit Öğe Kaydı
dc.contributor.authorGarcı, Amine
dc.contributor.authorMbakidi, Jean-Pierre
dc.contributor.authorChaleix, Vincent
dc.contributor.authorSol, Vincent
dc.contributor.authorOrhan, Ersin
dc.contributor.authorTherrien, Bruno
dc.date.accessioned2020-04-30T23:46:49Z
dc.date.available2020-04-30T23:46:49Z
dc.date.issued2015
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionsol, vincent/0000-0003-0175-0156; orhan, ersin/0000-0002-5461-1005; chaleix, vincent/0000-0002-5324-3095; Therrien, Bruno/0000-0002-0388-2745en_US
dc.descriptionWOS: 000360322500028en_US
dc.description.abstractThree neutral dinuclear p-cymene ruthenium complexes (1a-1c) of the general formula (p-cymene)(2)Ru-2(mu(4)-L)Cl-2, bridged by substituted hydroxybenzoquinonato spacers (L-a = 2,5-dihydroxy-3-pheny1-1,4-benzoquinonato; L-b = 2,5-dihydroxy-3,6-diphenyl-1,4-benzoquinonato; L-c = 2,5-dihydroxy-3,6-(3,5-dimethylphenyl)-1,4-benzoquinonato) have been synthesized and characterized. The corresponding p-cymene ruthenium metallaprisms, [{(p-cymene)(2)Ru-2(mu(4)-L)}(3)(tpt)(2)][CF3SO3](6) (2a-2c), were obtained by mixing in methanol the neutral dinuclear complexes 1a-1c, AgCF3SO3, and 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine (tpt). In a similar fashion, addition of porphin during the formation of the metallaprisms afforded the host guest systems [porphin subset of{(p-cymene)(2)Ru-2(mu(4)-L)}(3)(tpt)(2)][CF3SO3](6) ([porphin subset of 2][CF3SO3](6)). The biological activity of all complexes was estimated on the colon cancer cell line HT-29, showing low cytotoxicity in the dark (IC50 > 5 mu M). On the other hand, the phototoxicity of the porphin-in-the-cage systems under standard irradiation conditions (20 J/cm(2)) is quite spectacular, being in the lower nanomolar range for [porphin subset of 2c] [CF3SO3](6).en_US
dc.description.sponsorshipFonds National Suisse de la Recherche Scientifique [200020_152552]en_US
dc.description.sponsorshipThe authors are grateful to the Fonds National Suisse de la Recherche Scientifique for financial support (grant 200020_152552).en_US
dc.identifier.doi10.1021/acs.organomet.5b00555en_US
dc.identifier.endpage4146en_US
dc.identifier.issn0276-7333
dc.identifier.issn1520-6041
dc.identifier.issue16en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage4138en_US
dc.identifier.urihttps://doi.org/10.1021/acs.organomet.5b00555
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5279
dc.identifier.volume34en_US
dc.identifier.wosWOS:000360322500028en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofOrganometallicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleTunable Arene Ruthenium Metallaprisms to Transport, Shield, and Release Porphin in Cancer Cellsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
5279.pdf
Boyut:
2.64 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu