Fitmix: An R Package for Mixture Modeling of the Budding Yeast S. cerevisiae Replicative Lifespan (RLS) Distributions

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dc.contributor.authorGuven, Emine
dc.contributor.authorQin, Hong
dc.date.accessioned2021-12-01T18:48:56Z
dc.date.available2021-12-01T18:48:56Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractReplicative lifespan (RLS) of the budding yeast is the number of mother cell divisions until senescence and is instrumental to understanding mechanisms of cellular aging. Recent research has shown that replicative aging is heterogeneous, which argues for mixture modeling. The mixture model is a statistical method to infer subpopulations of the heterogeneous population. Mixture modeling is a relatively underdeveloped area in the study of cellular aging. There is no open access software currently available that assists extensive comparison among mixture modeling methods. To address these needs, we developed an R package called fitmix that facilitates the computation of well-known distributions utilized for RLS data and other lifetime datasets. This package can generate a group of functions for the estimation of probability distributions and simulation of random observations from well-known finite mixture models including Gompertz, Log-logistic, Log-normal, and Weibull models. To estimate and compute the maximum likelihood estimates of the model parameters, the Expectation-Maximization (EM) algorithm is employed.en_US
dc.description.sponsorshipNSFNational Science Foundation (NSF) [1453078, 1720215, 1761839]en_US
dc.description.sponsorshipHQ thanks the support of NSF Career award #1453078 and #1720215, NSF BD Spoke #1761839.en_US
dc.identifier.doi10.3390/app11136114
dc.identifier.issn2076-3417
dc.identifier.issue13en_US
dc.identifier.scopus2-s2.0-85109878773en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/app11136114
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10634
dc.identifier.volume11en_US
dc.identifier.wosWOS:000670691400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofApplied Sciences-Baselen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectyeast agingen_US
dc.subjectmixture modelingen_US
dc.subjectGompertz mixture modelen_US
dc.subjectWeibull mixture modelen_US
dc.subjectmaximum likelihood estimationen_US
dc.subjectExpectation-Maximization (EM)en_US
dc.subjectGompertzen_US
dc.subjectWeibullen_US
dc.subjectExtensionen_US
dc.titleFitmix: An R Package for Mixture Modeling of the Budding Yeast S. cerevisiae Replicative Lifespan (RLS) Distributionsen_US
dc.typeArticleen_US

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