Prognostic significance of blood group antigen expression of tumor tissue in lung cancer patients

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dc.contributor.authorÜlger, Ayşe Füsun
dc.contributor.authorKeklik, Tülay
dc.contributor.authorÖzdemir, Özlem Kumbasar
dc.contributor.authorArbak, Peri
dc.contributor.authorDemirkazık, Ahmet
dc.contributor.authorGüngör, Adem
dc.contributor.authorAlper, Doğanay
dc.date.accessioned2020-04-30T23:21:46Z
dc.date.available2020-04-30T23:21:46Z
dc.date.issued2002
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000179685900009en_US
dc.descriptionPubMed: 12487558en_US
dc.description.abstractAims and background: Many prognostic factors have been evaluated both for SCLC and NSCLC. The prognostic significance of blood group antigen expression of tumor tissues has been studied particularly in NSCLC, yielding divergent results. The aim of the present study was to investigate the prognostic value of the tumoral expression of blood group antigens ABH in lung cancer. Methods: The presence of blood group antigens was assessed immunohistochemically in paraffin-embedded tumor samples from 92 patients diagnosed between 1996 and 1997. Monoclonal antibodies were used to detect blood group antigens. Results: The median survival was longer in NSCLC patients whose tumors were positive for blood group antigen A (P = 0.009). Since the expression of blood group antigen A in tumor cells was limited to patients with type A or AB blood, survival analysis of these patients showed survival to be longer in non-small cell lung cancer patients with blood group antigen A-positive tumors (P = 0.0019). Conclusions: Expression of blood group antigen A in tumor cells is an important, favorable prognostic factor in patients with non-small cell lung cancer, which could be useful to stratify patients with blood group A or AB according to possible outcome, and to guide therapeutic decision-making. The expression of blood group antigens ABH should be evaluated in larger series of lung cancer patients (including small and non-small cell lung cancer) with all blood types.en_US
dc.identifier.endpage399en_US
dc.identifier.issn0300-8916
dc.identifier.issn2038-2529
dc.identifier.issue5en_US
dc.identifier.startpage395en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4247
dc.identifier.volume88en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofTumori Jen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectblood group antigensen_US
dc.subjectlung canceren_US
dc.subjectprognosisen_US
dc.titlePrognostic significance of blood group antigen expression of tumor tissue in lung cancer patientsen_US
dc.typeArticleen_US

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