Investigation of The Effects of Fatty Acids on Growth Hormone, Insulin-like Growth Factor 1, and Insulin- and Hormone-sensitive Lipase Levels in Rats

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dc.authoridGOK, Ali/0000-0003-4103-9537;
dc.contributor.authorEmir, Aysegul
dc.contributor.authorBeyazcicek, Ozge
dc.contributor.authorBeyazcicek, Ersin
dc.contributor.authorGok, Ali
dc.date.accessioned2025-10-11T20:47:39Z
dc.date.available2025-10-11T20:47:39Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: Several studies have investigated hormones such as growth hormone (GH), insulin (INS), insulin-like growth factor-1 (IGF-1), and hormone- sensitive lipase (HSL). However, there is insufficient data on the effects of the combination of short-, medium-, and long-chain fatty acids on hormone concentrations in serum/tissue, including GH, INS, IGF-1, and HSL. The purpose of this study was to investigate the effects of butyric acid (BA), caprylic acid (CA), and oleic acid (OA) alone or in combination on GH, INS, IGF-1, and HSL secretion. Methods: Fifty-six male Wistar rats were used in the study. The animals were separated into 8 subgroups: control, BA, CA, OA, BA + CA, BA + OA, CA + OA, and BA + CA + OA groups. Fatty acids were administered orally to rats for 21 days. At the end of the study, GH, IGF, INS, and HSL levels were measured in serum using the enzyme-linked immunosorbent assay method. Results: BA administration reduced GH, IGF-1, and INS levels but had no significant effect on HSL levels. CA administration increased HSL levels but had no significant effect on GH, INS, and IGF-1 levels. OA administration increased GH and HSL levels but had no significant effect on IGF-1 and INS levels. Conclusion: The combined use of fatty acids increased GH levels while decreasing INS, IGF-1, and HSL levels.en_US
dc.description.sponsorshipDzce University Research Fund [2023.04.01.1393]en_US
dc.description.sponsorshipThis project is supported by Duezce University Research Fund project number: 2023.04.01.1393.en_US
dc.identifier.doi10.4274/jarem.galenos.2024.82621
dc.identifier.endpage66en_US
dc.identifier.issn2146-6505
dc.identifier.issn2147-1894
dc.identifier.issue2en_US
dc.identifier.startpage60en_US
dc.identifier.trdizinid1280943en_US
dc.identifier.urihttps://doi.org/10.4274/jarem.galenos.2024.82621
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1280943
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21507
dc.identifier.volume14en_US
dc.identifier.wosWOS:001314973400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal of Academic Research in Medicine-Jaremen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectButyric aciden_US
dc.subjectcaprylic aciden_US
dc.subjectoleic aciden_US
dc.titleInvestigation of The Effects of Fatty Acids on Growth Hormone, Insulin-like Growth Factor 1, and Insulin- and Hormone-sensitive Lipase Levels in Ratsen_US
dc.typeArticleen_US

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