Effects of food preservative natamycin on liver enzymes and total protein in Mus musculus

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dc.contributor.authorRasgele, Pınar Göç
dc.contributor.authorKaymak, Fisun
dc.date.accessioned2020-04-30T13:32:24Z
dc.date.available2020-04-30T13:32:24Z
dc.date.issued2013
dc.departmentDÜ, Rektörlük, Arıcılık Araştırma, Geliştirme ve Uygulama Merkezien_US
dc.description.abstractNatamycin is a food preservative of which is used to inhibit yeast and fungi growth on cheese and sausages. In the present study, effects of natamycin on the levels of liver enzymes and total protein were investigated in mice by using serum enzyme activity assay. Natamycin was intraperitoneally injected to female and male mice at 200, 400and 800 mg/kg for 6, 12 and 24 hours. Blood samples were taken for determination of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, total protein and all of samples were performed by using a spectrophometer. The present results revealed a significant increase in the levels of ALT of female and male mice treated with different concentrations of natamycin when compared with the negative control. Furthermore, natamycin induced a significant decrease in serum LDH and AL P in female and male mice, respectively. In conclusion, natamycin may affect adversely and cause degenerative disorders in liver, and so it may alter levels of enzymes in liver being a vital organ.en_US
dc.identifier.endpage302en_US
dc.identifier.issn1310-0351
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage298en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/272
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofBulgarian Journal of Agricultural Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFood preservative; Liver enzymes; Mice; Natamycin; Total proteinen_US
dc.titleEffects of food preservative natamycin on liver enzymes and total protein in Mus musculusen_US
dc.typeArticleen_US

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