Investigation of the Acute Subacute Toxicity of KL21® Supplementary Food Product in Rats

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dc.contributor.authorGök, Ali
dc.contributor.authorYasar, Mustafa
dc.contributor.authorSaraç, Güliz
dc.contributor.authorSipahi, Nisa
dc.contributor.authorAğan, Aydan Fülden
dc.date.accessioned2024-08-23T16:08:13Z
dc.date.available2024-08-23T16:08:13Z
dc.date.issued2022en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: KL21®; It is a food supplement using remember regeneration therapy method (RTM). KL21®. Whereas products that containing combined medicinal plants are expected to be beneficial for health, on the other hand, their toxic properties are able to potentially increase due to the interactions of the active ingredients in the plants. With this study, it was aimed to investigate the toxic effect of KL21®. Material-Method: In the study conducted with control (n: 8), acute (n: 8), subacute (n: 8) and post-subacute (n: 8) groups; the daily dose of the product was tested by gavage in 8-week-old female Wistar rats. Biochemical parameters P, Ca, ALB, TG, TP, TC, Creatinine, Bilirubin, GGT, ALP, AST and ALT were analyzed. In hematological parameters; WBC, RBC, PLT, HCT, HGB were examined. Liver, lung, spleen, kidney and heart tissues were investigated histopathologicaly. Clinical observation was made throughout the entire process. Results: When the acute, subacute and post-subacute groups were compared to control, it was observed that there was no significant difference in biochemical, hematological, histopathological terms. No toxicity-related side effects were found in clinical observations. Conclusion: The potential toxic effect of daily use dose of KL21® containing the combined medicinal plant was investigated in vivo. According to the hemogram, biochemistry and pathology tests, it was determined that it does not show acute and subacute toxicity.en_US
dc.identifier.doi10.53811/ijtcmr.1121162
dc.identifier.endpage196en_US
dc.identifier.issue3en_US
dc.identifier.startpage190en_US
dc.identifier.trdizinid1144491en_US
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1144491
dc.identifier.urihttps://hdl.handle.net/20.500.12684/15165
dc.identifier.volume3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofInternational journal of traditional and complementary medicine research (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInvestigation of the Acute Subacute Toxicity of KL21® Supplementary Food Product in Ratsen_US
dc.typeArticleen_US

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