Experimental Animal Models in Respiratory Diseases

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dc.authorscopusid57199508851en_US
dc.contributor.authorYildiz, Gülhan, P.
dc.date.accessioned2024-08-23T16:07:30Z
dc.date.available2024-08-23T16:07:30Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractRespiratory diseases are among the leading causes of morbidity and mortality worldwide. Various animal models are used to understand the pathogenesis of these diseases and develop novel therapeutic strategies. Each model offers the opportunity to examine the multifaceted nature of pulmonary health, from common afflictions such as asthma and chronic obstructive pulmonary disease (COPD) to interstitial lung diseases. While these models provide a unique opportunity to understand normal physiology and disease pathophysiology and to test potential treatments for diseases, all animal models have inherent limitations. This review focuses on experimental models of common respiratory diseases such as asthma, COPD, and pulmonary fibrosis. The advantages, disadvantages, and translational potential to human disease of each model are discussed. Asthma models include mice, guinea pigs, and Drosophila, while elastase-induced emphysema, cigarette smoke exposure, and genetically modified mice are used for COPD. For pulmonary fibrosis, bleomycin, adenoviral TGF-?1 vector, silica, and genetically modified mice models are available. These models have provided valuable insights into disease mechanisms and aided in identifying new therapeutic targets. However, it is important to note that no single model fully recapitulates human disease, and each has its own unique advantages and limitations. Therefore, careful consideration of the translatability of findings from preclinical studies to humans is crucial. © 2024, Duzce University Medical School. All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.1503737
dc.identifier.endpage54en_US
dc.identifier.issn1307-671X
dc.identifier.issueS1en_US
dc.identifier.scopus2-s2.0-85197502472en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.1503737
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14688
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYildiz, Gülhan, P.en_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExperimental animalen_US
dc.subjectlung diseasesen_US
dc.subjectpathogenesisen_US
dc.subjectbleomycinen_US
dc.subjectsilicon dioxideen_US
dc.subjecttransforming growth factor beta1en_US
dc.subjectanimal modelen_US
dc.subjectasthmaen_US
dc.subjectchronic obstructive lung diseaseen_US
dc.subjectcigarette smokeen_US
dc.subjectdrug administrationen_US
dc.subjectelastase-induced emphysemaen_US
dc.subjectetiologyen_US
dc.subjectgenetically engineered mouse strainen_US
dc.subjectguinea pigen_US
dc.subjecthumanen_US
dc.subjectinterstitial lung diseaseen_US
dc.subjectlung diseaseen_US
dc.subjectlung fibrosisen_US
dc.subjectmortalityen_US
dc.subjectmouseen_US
dc.subjectnonhumanen_US
dc.subjectpathogenesisen_US
dc.subjectpathophysiologyen_US
dc.subjectrespiratory tract diseaseen_US
dc.subjectreviewen_US
dc.titleExperimental Animal Models in Respiratory Diseasesen_US
dc.title.alternativeSolunum Hastalıklarında Deneysel Hayvan Modellerien_US
dc.typeReviewen_US

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