The Effect Of L-Carnitine And Alpha Lipoic Acid Administration With Exercise In Old Rats On Energy Metabolism Related To Oxidative Stress Parameters

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dc.authorid/0000-0003-4103-9537en_US
dc.authoridYildiz Gulhan, Pinar/0000-0002-5347-2365en_US
dc.authorwosid/AAA-9431-2021en_US
dc.contributor.authorKalkan, Kardelen Kocaman
dc.contributor.authorSirin, Neslihan
dc.contributor.authorTepe, Atakan
dc.contributor.authorGok, Ali
dc.contributor.authorAltas, Tolga
dc.contributor.authorAgan, Kagan
dc.contributor.authorGulhan, Pinar Yildiz
dc.date.accessioned2024-08-23T16:03:38Z
dc.date.available2024-08-23T16:03:38Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: This study aims to contribute novel insights by investigating the potential positive effects of a combined dietary supplement and exercise program on mitochondrial oxidative stress and energy metabolism in aging. Focusing on the protective impact of Alpha Lipoic Acid (ALA), a potent antioxidant, against exercise-induced mitochondrial oxidative stress in rats, we also assess how L-Carnitine administration affects exercise ability by analyzing resistin and HbA1c levels, indicators linked to insulin resistance and cellular sensitivity. Method: In this 10-day study, 42 old male Sprague Dawley rats (weighing 400 +/- 10 g, aged 15-17 weeks) were divided into six groups (n=7): Control, Exercise, L-Carnitine, Alpha Lipoic Acid (ALA), L-Carnitine+Exercise, ALA+Exercise. Relevant groups received daily oral gavage doses of L - Carnitine (50 mg/ml) and ALA (18 mg/ml). Exercise groups underwent treadmill sessions. On day 10, blood samples were quantitatively analyzed for HbA1c and Resistin levels using a Cusabio ELISA assay kit (China). Results: ALA supplementation synergistically reduced resistin and HbA1c levels, individually and combined with exercise. Conversely, L-Carnitine supplement, alone or with exercise, increased resistin levels but it caused a decrease in HbA1c levels. Conclusion: The data indicated a minor, insignificant decrease in resistin levels for the exercise and ALA groups, with a statistically significant difference in HbA1c levels among all groups. Exercise alone positively impacted both HbA1c and resistin levels, suggesting a potential counteraction of age-related oxidative stress and a positive influence on energy metabolism through an appropriate diet and exercise program. Further studies are required to explore specific metabolic pathways and relationships identified in our findings.en_US
dc.identifier.doi10.33808/clinexphealthsci.1369239
dc.identifier.endpage483en_US
dc.identifier.issn2459-1459
dc.identifier.issue2en_US
dc.identifier.startpage476en_US
dc.identifier.trdizinid1250859en_US
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.1369239
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1250859
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13836
dc.identifier.volume14en_US
dc.identifier.wosWOS:001273864700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Inst Health Sciencesen_US
dc.relation.ispartofClinical And Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgingen_US
dc.subjectexerciseen_US
dc.subjectresistinen_US
dc.subjectHbA1cen_US
dc.subjectoxidative stressen_US
dc.subjectMolecular-Mechanismsen_US
dc.subjectSupplementationen_US
dc.subjectObesityen_US
dc.titleThe Effect Of L-Carnitine And Alpha Lipoic Acid Administration With Exercise In Old Rats On Energy Metabolism Related To Oxidative Stress Parametersen_US
dc.typeArticleen_US

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