Effects of thrombus characteristics on clinical outcome and success of recanalization in acute ischemic stroke

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dc.authoridCAKIR, EZGI AYSE/0000-0001-7695-8192
dc.authoridSahan, Halime/0000-0003-4329-7011
dc.authoridyabalak, ahmet/0000-0002-3317-9567
dc.authoridOnalan, Aysenur/0000-0002-9939-2678;
dc.contributor.authorYabalak, Ahmet
dc.contributor.authorOgun, Muhammed Nur
dc.contributor.authorDuzelitmeli, Ayse Onalan Isimler
dc.contributor.authorKarahan, Ezgi Ayse cakir
dc.contributor.authorSahan, Halime
dc.contributor.authorTokmak, Hilmiye
dc.date.accessioned2025-10-11T20:47:37Z
dc.date.available2025-10-11T20:47:37Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: Despite current developments in mechanical thrombectomy (MT), successful recanalization cannot be achieved in all patients. One of the factors related to this is the characteristics of the thrombus. In this study, we aimed to evaluate the effects of thrombus length and permeability on procedural success and clinical outcome. Methods: Patients with intracranial ICA, middle cerebral artery M1, or M2 occlusions, who underwent MT between November 2019 and January 2022 were included in the study. Thrombus length, density and permeability were calculated and the relationship between recanalization success and modified Rankin Scores (mRS) at the 3rd month was evaluated. Good clinical outcome was defined as an mRS score of 2 or less. Results: Forty-six of the 79 patients included in the study had a good clinical outcome. Although thrombus length was shorter and permeability was higher in patients with good clinical outcome, statistical significance was not achieved. There was a positive correlation between thrombus density, thrombus length and the number of passes, and a negative correlation between permeability. There was no significant difference in thrombus length, density and permeability between patients with and without successful recanalisation. Thrombus length was found to be a predictor of clinical outcome at 3 months in univariate analysis, whereas only age was found to be an independent predictor in multivariate analysis. Conclusions: In conclusion, despite certain findings not achieving statistical significance, the observed trends offer valuable insights for future research. A comprehensive understanding of thrombus nature could guide personalized stroke treatment strategies in the future.en_US
dc.identifier.doi10.54029/2024mfs
dc.identifier.endpage572en_US
dc.identifier.issn1823-6138
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85208597703en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage565en_US
dc.identifier.urihttps://doi.org/10.54029/2024mfs
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21479
dc.identifier.volume29en_US
dc.identifier.wosWOS:001403244400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAsean Neurological Assocen_US
dc.relation.ispartofNeurology Asiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectStrokeen_US
dc.subjectThrombus lengthen_US
dc.subjectThrombus permeabilityen_US
dc.subjectEndovascular treatmenten_US
dc.subjectThrombectomyen_US
dc.titleEffects of thrombus characteristics on clinical outcome and success of recanalization in acute ischemic strokeen_US
dc.typeArticleen_US

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