Investigation of Neutrophil Volume, Conductivity, and Light-Scattering Parameters for Early Diagnosis of Bacterial Infections

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dc.contributor.authorAytar, Asiye Altınöz
dc.contributor.authorDoğan, Özlem
dc.contributor.authorÇalışkan, Emel
dc.date.accessioned2023-07-26T11:55:12Z
dc.date.available2023-07-26T11:55:12Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractAim: Early diagnosis of bacterial infections is crucial in planning treatment. Thus, it is important to determine the gram staining property of bacteria as well as the presence of bacterial infection. The acute bacterial infection leads to morphological changes in neutrophils. In this study, we investigated the use of neutrophil volume, conductivity and light-scattering (VCS) parameters as potential indicators for rapid diagnosis of bacterial infections, and to distinguish infections caused by gram-positive and gram-negative bacteria. Material and Methods: Patients with urinary tract infections, pneumonia, wound site infections and sepsis were included. The control group comprised patients without bacterial infections. The blood samples of the patients were examined for white blood cell and neutrophil counts; neutrophil VCS parameters were determined using a Coulter Analyzer. The VITEK 2 Compact System was used to detect microbial growth. Results: The blood sample data of 472 patients sent to our laboratory for Complete Blood Count analyses from various clinics were analyzed in this study. A total of 370 samples showed significant growth in their bacteriological culturing, whereas the remaining 102 samples showed no growth. For the detection of bacterial growth, the specificities of median neutrophil volume (MNV) and median neutrophil conductivity (MNC) were found to be 96% and 99%, respectively. In addition, median neutrophil light scattering (MNS) was higher in the gram-negative bacterial group than in the gram-positive bacterial group. Conclusion: The use of neutrophil VCS parameters is an effective and time-saving method to identify bacterial infections and distinguish between gram-positive and gram-negative bacterial infections.en_US
dc.identifier.doi10.33631/sabd.1171636
dc.identifier.endpage473en_US
dc.identifier.issn2792-0542
dc.identifier.issue3en_US
dc.identifier.startpage468en_US
dc.identifier.trdizinid1124755en_US
dc.identifier.urihttp://doi.org/10.33631/sabd.1171636
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1124755
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13020
dc.identifier.volume12en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorÇalışkan, Emel
dc.language.isoenen_US
dc.relation.ispartofSağlık Bilimlerinde Değer (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectBacteriaen_US
dc.subjectinfectionen_US
dc.subjectneutrophilen_US
dc.subjectVCS parametersen_US
dc.titleInvestigation of Neutrophil Volume, Conductivity, and Light-Scattering Parameters for Early Diagnosis of Bacterial Infectionsen_US
dc.typeArticleen_US

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