In Vivo Assessment of the Effect of Hexagonal Boron Nitride Nanoparticles on Biochemical, Histopathological, Oxidant and Antioxidant Status

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dc.authoridkar, fatih/0000-0001-8356-9806
dc.authoridGONCU, Yapincak/0000-0002-8602-9765
dc.authorwosidSogut, Ibrahim/AAU-9306-2021
dc.authorwosidkar, fatih/AAI-4540-2021
dc.authorwosidkar, fatih/AAN-4285-2021
dc.authorwosidhacioglu, ceyhan/ABB-5317-2020
dc.authorwosidGONCU, Yapincak/AAO-3601-2020
dc.contributor.authorKar, Fatih
dc.contributor.authorHacioglu, Ceyhan
dc.contributor.authorGoncu, Yapincak
dc.contributor.authorSogut, Ibrahim
dc.contributor.authorSenturk, Hakan
dc.contributor.authorDonmez, Dilek Burukoglu
dc.contributor.authorAy, Nuran
dc.date.accessioned2021-12-01T18:50:53Z
dc.date.available2021-12-01T18:50:53Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractThe aim of our study is to investigate the dose-dependent biological system effect of hexagonal boron nitride (hBN) nanoparticles, which is directly produced nanoscale, in vivo. Wistar albino rats (n = 80) weighing 200-250 g were divided into eight groups (n = 10). The acute effects of hBN NPs (i.v) on the rats were investigated by measuring the biochemical, hematological parameters and oxidant-antioxidant status. The results show that no significant change was observed in the hematological and biochemical parameters when the control group and other low dose groups were compared, except for the 1600 and 3200 mu g/kg b.w. dose groups. Histological detection indicated that 1600 and 3200 mu g/kg hBN NPs treatment could induce significant damage in the liver, kidney, heart, spleen and pancreas. With the findings obtained, it can be seen that hBN NPs cannot be evaluated independently of particle morphology, and that the hBN NPs used in this study may be suitable for biomedical applications where low doses between 50 and 800 mu g/kg are not toxic.en_US
dc.description.sponsorshipEskiehir Technical University Scientific Research Projects Commission [19ADP163]en_US
dc.description.sponsorshipThis study was supported by Eskiehir Technical University Scientific Research Projects Commission. (Project No: 19ADP163). The authors would like to thank BORTEK Boron Technologies and Mechatronic Inc. for their material support and Dr. Umut SAVACI for his help to use Transmission Electron Microscopy (TEM) (Eskisehir Technical University, Turkey).en_US
dc.identifier.doi10.1007/s10876-020-01811-w
dc.identifier.endpage529en_US
dc.identifier.issn1040-7278
dc.identifier.issn1572-8862
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85085019778en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage517en_US
dc.identifier.urihttps://doi.org/10.1007/s10876-020-01811-w
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10940
dc.identifier.volume32en_US
dc.identifier.wosWOS:000533059200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofJournal Of Cluster Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHexagonal boron nitrideen_US
dc.subjectRaten_US
dc.subjectSerumen_US
dc.subjectCytotoxicityen_US
dc.subjectOxidative stressen_US
dc.subjectPotential Applicationsen_US
dc.subjectGlycol-Chitosanen_US
dc.subjectNanotubesen_US
dc.subjectToxicityen_US
dc.subjectCytocompatibilityen_US
dc.subjectBiocompatibilityen_US
dc.titleIn Vivo Assessment of the Effect of Hexagonal Boron Nitride Nanoparticles on Biochemical, Histopathological, Oxidant and Antioxidant Statusen_US
dc.typeArticleen_US

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