Comparison of the Effects of Nigella sativa Oil and Nano-silver on Wound Healing in an Experimental Rat Model

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dc.contributor.authorTurhan, Yalçın
dc.contributor.authorArıcan, Mehmet
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorTurhal, Ozan
dc.contributor.authorGamsızkan, Mehmet
dc.contributor.authorAydın, Davut
dc.contributor.authorÖzkan, Korhan
dc.date.accessioned2020-04-30T22:41:28Z
dc.date.available2020-04-30T22:41:28Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionkaraduman, zekeriya okan/0000-0002-6719-3666en_US
dc.descriptionWOS: 000459169000010en_US
dc.description.abstractBackground: Various topical treatments are available for skin defects. Chronic and complicated wounds can affect a patient's quality of life and cause significant economic burden and even mortality. Nigella sativa (NS) oil and silver-containing solutions are separately used to treat various skin disorders. Objectives: The current study aimed at examining the healing potential of NS oil, Nano-silver (AgNPs) solution, and their combination to manage skin wounds in a rat model. Methods: The current clinical experimental study was conducted in the Experimental Animal Unit of Abant Izzet Baysal University, Bolu, Turkey, in 2017. Full-thickness skin defects with a 1 cm(2) surface area were created on the backs of 20 adult Wistar albino rats. The wounds were covered with 1 cm(2) of absorbable oxidized regenerated cellulose (SURGICEL). The rats were numbered and assigned to four groups by simple random sampling. The agents to be compared (saline, NS oil, and AgNPs solution) were administered to the wounds twice daily forts days. The wounds were observed for the percentage reduction in original wound size every three days. Scars were harvested on day15 for histological morphometric analysis. Results: There were no significant differences in the mean vertical scar thickness among the saline (group 1) [1.06 +/- 0.18], NS oil (group 2) [0.76 +/- 0.14], AgNPs (group 3)10.98 +/- 0.44], and NS oil + AgNPs (group 4) [0.87 +/- 0.38] groups (P = 0.556). However, the mean collagen density was significantly lower in groups 1 and 3 [56.50 +/- 11.18 and 59.60 +/- 3.16] compared with groups 2 and 4 [73.57 +/- 6.30 and 80.99 +/- 7.19] (P < 0.001). Conclusions: Wounds treated with the combination of NS oil and Nano-silver healed significantly faster, with less scar formation, than the ones treated with NS oil or Nano-silver alone.en_US
dc.identifier.doi10.5812/ircmj.84650en_US
dc.identifier.issn2074-1804
dc.identifier.issn2074-1812
dc.identifier.issue1en_US
dc.identifier.urihttps://doi.org/10.5812/ircmj.84650
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3192
dc.identifier.volume21en_US
dc.identifier.wosWOS:000459169000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKowsar Publen_US
dc.relation.ispartofIranian Red Crescent Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHealingen_US
dc.subjectNano-silveren_US
dc.subjectNigella sativaen_US
dc.subjectOilen_US
dc.subjectRatsen_US
dc.subjectScaren_US
dc.subjectSkinen_US
dc.subjectWounden_US
dc.titleComparison of the Effects of Nigella sativa Oil and Nano-silver on Wound Healing in an Experimental Rat Modelen_US
dc.typeArticleen_US

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